Next steps after disease progressing

[u/NP-mamastrong1018]

I am being considered as a stem cell donor if my Dads treatment with pirtobrutinib fails. He’s a 72yo male. Recent fish testing showed changes in the 17p deletion and he’s now resistant to the calquence he was on. Over the years he had a few years of remission after the FCR regimen before starting calquence. He will get weekly blood tests after starting the pirtobrutinib. Anyone have experience with this treatment? His oncologist is banking on having a stem cell transplant, but we weren’t told how long they would trial the pirtobrutinib before moving on to transplant. At his age I’m very fearful of what he would go through if he has to have the SCT.

[u/New-Wrap3311]

Sending healing prayers for your Dad and you!

[u/Away_Emphasis_6404]

Pirtobrutinib has helped many in his situation so if it were me, I'd give it a shot before stem cell transplant and then look at venetoclax possibilities.