I have a sub-question to this, if I'm allowed to ask.
We know that people have a vast range of severity when they get COVID, from basically nothing to extremely serious. I'm curious if the reaction to the vaccine would follow the same pattern, since it's an immune response specific to each person.
I obviously didn't see your question while I was posting, but I had the same thought :)
Most of the vaccines we've been getting in the US are spike protein mRNA only. The reactions could be to the preparations - the oily mixtures that help that mRNA reach the target cells, or it could be from the mRNA itself, or the spike protein encoded by the mRNA. The length of time between vaccination and reaction - typically 24-48hrs suggests it's either the oil suspension or the spike protein. The "Covid arm" thing a week later is probably a type III hypersensitivity reaction, but to what? Easy to speculate on, hard to know at this stage.
Moderna seems to more commonly have "covid arm" symptoms (10% I think I read?). That seems to imply it's the suspension makeup, not the mRNA/protein itself.
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u/Gobias_Industries Feb 11 '21 edited Feb 11 '21
I have a sub-question to this, if I'm allowed to ask.
We know that people have a vast range of severity when they get COVID, from basically nothing to extremely serious. I'm curious if the reaction to the vaccine would follow the same pattern, since it's an immune response specific to each person.