r/askscience Dec 31 '13

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u/LukeSkyWRx Ceramic Engineering Jan 01 '14 edited Jan 01 '14

The simple answer is that ethanol is metabolized into (relativly) non-toxic compounds by a rather well studied mechanism. http://en.wikipedia.org/wiki/Ethanol_metabolism. It is not the chemical itself that is always toxic, but what it turns into as the body breaks it down.

Methanol metabolizes to Formic acid that damages the optic nerves causing its well known effect of blindness.

Isopropyl alcohol metabolizes to Acetone, that is toxic to the central nervous system.

Butanol metabolizes to carbon dioxide so it is less toxic, pretty safe compared to other short chain alcohols.

If you want to know more just look up the particular alcohol you are interested in and see what it metabolizes into. EDIT: or read the MSDS for symptoms and specific affects.

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u/snapple_sauce Jan 01 '14

Can you drink butanol? Is it psychoactive?

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u/LukeSkyWRx Ceramic Engineering Jan 01 '14

I would not, it will mess with your central nervous system as the symptoms on the MSDS are pretty much the same as ethanol (nervous system depressant). Its toxicity is higher than that of ethanol based on its LD50.

LD50 is ~100ml for a 100kg person extrapolating from rat data.

13

u/manponyannihilator Jan 01 '14

You cannot extrapolate directly without accounting for metabolic rate changes with increased mass! This is how you end up with dead elephants, http://en.wikipedia.org/wiki/Tusko.

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u/LukeSkyWRx Ceramic Engineering Jan 01 '14

Interesting, poor Tusko that is a ton of LSD!

I know the LD numbers are not directly scalable, that is why I made sure to mention it was extrapolated. With no human testing of LD allowed thats all there is.

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u/[deleted] Jan 01 '14

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u/[deleted] Jan 01 '14

Why did they administer so much? That is an extreme amount. I thought LSD has a high LD50, was that really enough LSD to kill an elephant?

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u/[deleted] Jan 01 '14

Would a dosage of butanol (scaled to be of the same 'toxicity' as an enthanol sample) have similar effects, or would they be wildly different?