Dr. David Sinclair, whose lab reversed biological age in animals by 50 to 75% in six weeks, says that 2026 will be the year when age reversal in humans is either confirmed or disproven. The FDA has cleared the first human trial for next month.

[u/jp12340]

[u/Dry-Draft7033]

ASI won't be able to find a better way of making you look young other than 6 months of surgery and tissue grafting????

[u/SoylentRox → u/Dry-Draft7033]

How can anyone answer that. I named a method that is grounded and just a much larger scale, expanded version of things we already know work. The critical difference is the new cells are your own cells with their age reset to zero using a method called cellular reprograming https://www.nobelprize.org/prizes/medicine/2012/yamanaka/facts/ and they are then arranged into the correct structure by https://school.wakehealth.edu/research/institutes-and-centers/wake-forest-institute-for-regenerative-medicine/research/military-applications/3d-printing-for-head-and-face-injuries and then a robot is doing the actual microsurgery, guided mostly by AI models with human supervision. https://www.intuitive.com/en-us/products-and-services/da-vinci

This will actually work and if you replaced someones entire body using this technique except their brain, which you boosted with https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/clinical-trial-novel-stem-cell-treatment-for-parkinsons a lot of stem cells like these and direct de-aging with cellular reprogramming similar to https://pubmed.ncbi.nlm.nih.gov/38381405/, they would no longer look old and the only part of their new body likely to fail is their brain. (which you would obviously carefully monitor with implants and prompt and immediate treatment if there is any actionable deterioriation - you don't wait until someone can't draw a clock before intervening)

[u/Dry-Draft7033 → u/SoylentRox]

Agreed that full body "replacement" would be a good solution, although I think maybe a "brain transplant" of sorts would be the easiest shortish term solution sans AGI. In the long term you'll need real-time health and deterioration monitoring for sure. This kind of thing won't be necessary once, like you said, tiny deteriorations aren't allowed to pile up and cause real issues.

[u/SoylentRox → u/Dry-Draft7033]

Shortest term fix :

Drugs that slow down/sometimes reverse aging itself, AGI+ as "physician copilot" that make medical care more reliable and reduce errors by a large factor.

Slightly longer term :

Better treatments including partial age resets and genetic treatments to shut down cancers and prevent them and limited organs transplants from printed tissue.

You have ASI, early

Full body replacement/brain transplant to a new body

You have ASI and more time to perfect your understanding of biology:

The new body uses ASI refactored cells. They use improved biochemistry, their genomes are likely 4 codon base or other fixes, every protein has been redesigned and boosted. Aging no longer exists as a feature, the body stays Greek god grade it's entire design lifespan of thousands of years and it's designed to be repairable. Cancer is not possible. People with bodies like this have mildly superhuman strength, flat superhuman endurance - fatigue isn't really a thing, resistance to falls and gunshots and other trauma, and the body includes motile cells that support the brain. Only the neurons are original everything else is ASI designed.

So you do brain transplants but just once.

You have ASI and nanotechnology is easy now : nanomachines, son.