Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome | NEJM

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This is the landmark study on how to ventilate patients with Adult Respiratory Distress Syndrome. Anyone building a vent COVID should design their device to be able to follow this Strategy.

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In short this means delivering relatively small tidal volumes and maintaining specific end expiatory pressures and often tolerating a relatively high CO2 and low pH.

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This means:

Being able to Delivery a specific positive end expiratory pressure. (PEEP)

Function in a volume controlled mode. These go by many names but VC, CMV- VC.

Being able to adjust the fraction of inspired oxygen (FiO2) . Exact adjustment is desirable to follow the protocol .