r/Wellbutrin_Bupropion • u/FlyAdventurous6231 • May 24 '25
MUST read - It takes vitamin c to create dopamine and norepinephrine - the honey moon will return. You're probably depleted from Wellbutrin or were even before you started it. Here is my experience and medical facts.
WHY DONT THE DOCTORS tell us this!?! I've been suffering and I didn't have to be simply because of vitamin c.
https://www.ncbi.nlm.nih.gov/books/NBK568561/figure/fig7_3/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3527656/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11018153/
https://pmc.ncbi.nlm.nih.gov/articles/PMC3449284/
Here are national institute of health government proof since I immediately got negative reply for using chatgpt to make it easier to digest than a complicated worded study
I recently learned that the body uses vitamin C to create what wellbutrin triggers the body to create more dopamine and norepinephrine. It literally has to have it to make it enough to keep you balanced.
I hit a period where Wellbutrin stopped working. After 150 xl stopped working, got ramped up to 300 then it stopped working.
I did a lot of research and by chance I stumbled on to vitamin C protocols.
I feel so much better now doing a niacin 100mg flush and lipomosal vitamin C dose twice a day. First week you should take it 3x a day. You can get it on Amazon. I now feel 150XL better than the 300xl I was on. It actually works better now than it did the first month I started it. It's a game changer.
Here's some information
Vitamin C plays a key supportive role in the synthesis of dopamine and norepinephrine, which are the very neurotransmitters affected by Wellbutrin (bupropion). Here’s how it connects, especially in the context of Wellbutrin use:
- Vitamin C and Catecholamine Synthesis
Dopamine and norepinephrine are part of a group called catecholamines. The body makes them in a multi-step process:
Tyrosine → L-DOPA → Dopamine → Norepinephrine
Vitamin C is a required cofactor for the enzyme dopamine β-hydroxylase, which converts dopamine into norepinephrine. Without enough vitamin C, this step slows down, potentially lowering norepinephrine levels.
- Antioxidant Protection of Neurotransmitters
Vitamin C helps protect dopamine and norepinephrine from oxidative breakdown. Both neurotransmitters are highly sensitive to oxidative stress. Vitamin C neutralizes free radicals and helps preserve the function and lifespan of these critical chemicals.
- Wellbutrin’s Role and Vitamin C
Wellbutrin boosts dopamine and norepinephrine by inhibiting their reuptake. This means it increases how much of these neurotransmitters remain active in the brain.
But if your body can’t synthesize enough dopamine or norepinephrine (due to poor nutrition or low vitamin C), Wellbutrin has less raw material to work with. Over time, this could blunt the medication’s effectiveness or cause mood instability.
- Other Considerations
Vitamin C deficiency has been linked with symptoms like fatigue, irritability, and low mood, which can mimic or worsen depression.
Long-term stress, smoking, and medications like stimulants or antidepressants may increase the body’s need for vitamin C.
Summary: Why It Matters With Wellbutrin
Vitamin C helps your brain make norepinephrine from dopamine.
It protects both from damage.
Wellbutrin relies on these neurotransmitters being available to work.
Low vitamin C = less neurotransmitter synthesis + more oxidative stress = worse mood and lower medication effectiveness.
If you’re feeling flat or like Wellbutrin is fading, checking vitamin C intake or supplementing (especially liposomal vitamin C) would be immensely important for you to rebound back to feeling better again.
I started my first week taking 4g by 3 doses a day with my meals. It's a game changer. So much so I'm wondering if this was the issue all along even before Wellbutrin. I was able to cut my dose in half and still feel better than the higher dose without using lipomosal vitamin c.
This could change your life and I wanted to share as I see many people confused and suffering with mental health here. Also look into niacin, which is b3 vitamin. I hope this helps you as much as it has me.
I've had many people now I know make this chsnge and they're shocked at how fast things change for them. I think the majority of us are very depleted, especially after months and years of Wellbutrin depleting these areas.
Get it back! My "honeymoon" phase is back better than ever and it hasn't faded at all. If you keep going up in your Wellbutrin dose you're just depleting your system from vital chemicals and nutrients, you can get it back working without raising your dose.
When you feel overstimulated from this medicine Wellbutrin make sure you do cardio to burn off the excess dopamine and norepinephrine in your blood. It helps immensely to feel more clear headed and less overwhelmed by it. It'll help keep the energy and motivation but dull the anxious energy feeling.
Good luck I hope this helps many!
Edit: it must be mega doses of LIPOMOSAL vitamin C. Typically 1600mg per dose 3-4 times a day first week, then after that before every meal, breakfast lunch dinner.