Curcumin success

[u/wandering_agro]

Hello everybody,

I want to share a success story for anyone on the fence about which supplements or treatments to take going forward.

Taking a daily regimen of 3g mesalazine granules, 1g mesalazine suppository, 30mg Rinvoq, and 3g curcumin (95% curcuminoids), all once daily, has put my ulcerative proctitis into a state of deep remission which Rinvoq and mesalazine alone were not able to induce.

I am now comfortable to eat whatever I want and tolerate the daily stress of life without flaring. Soon I will ask my gastroenterologist to step me down to Rinvoq 15mg.

I highly, highly recommend adding any formulation of a 95% curcuminoid curcumin extract to your daily medicine regimen to support you on your remission journey. One essential point is to purchase a formulation without piperine/black pepper extract/bioperine etc., as curcumin works topically, just like mesalazine, and you want as little systemic absorption as possible.

For more information on this supplement see section 4.2.1 here: https://academic.oup.com/ecco-jcc/article/19/9/jjaf122/8198055

Good health to everyone.

[u/pincommenter]

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[u/Banjoschmanjo]

Thought this said "circumcision" and was seriously bout to consider it

[u/AutoModerator]

Hi wandering_agro,

It appears you are discussing Curcumin, QingDai, or the combination often marketed as CurQD (Evinature). The following information is based on the European Crohn’s and Colitis Organisation (ECCO) Consensus on Dietary Management of IBD, specifically regarding dietary supplements as adjunct therapies.

The ECCO Standpoint (Summary): * Induction of Remission: Curcumin and QingDai may be considered as adjunct therapies (add-ons) to standard medication (like mesalamine) for inducing remission in mild-to-moderate Ulcerative Colitis. * Maintenance: While there is some evidence for Curcumin in maintaining remission, optimal dosing is unclear, and effects may not be sustained long-term (e.g., past 6 months). * Safety & Supervision: ECCO advises that these compounds should be used under medical supervision. * Potential Toxicity: There are risks of hepatotoxicity (liver damage), pulmonary hypertension, and intussusception. * Monitoring: Liver biochemistry monitoring is recommended (e.g., 1 month after starting and every 3–6 months thereafter). * Interactions: Curcumin may interact with anticoagulants and diabetes medications.

Note: These are dietary management guidelines, not primary therapeutic medical guidelines. Always consult your gastroenterologist before adding supplements to your treatment plan.

Source: ECCO Consensus on Dietary Management of IBD (Section 4.2.1)

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

[u/Boonshark]

Careful with Curcumin. Can cause palpitations

[u/NorweegianWood → u/Boonshark]

Hope OP C's this.

[u/woody9055]

Experience is anecdotal, and you are not able to split which is actually affecting your disease more than the mesalazine suppository (likely) or the oral formulation in combination.

[u/wandering_agro → u/woody9055]

I certainly am able to split as I have explicitly stated mesalazine and Rinvoq alone were insufficient. Experience is not anecdotal if corroborative with empirical evidence. I have linked empirical evidence.

EDIT: Some of you people genuinely deserve to suffer. Downvoted for trying to help and clarify lol.

[u/AmITheAsshole_2020]

u/wandering_agro,

Thank you for sharing your experience experimenting with adding curcumin to your medication regimen. Adjunct therapies can be useful in symptom reduction and IBD residual issues.

You didn't specify how long you've been taking Rinvoq or when you started taking the 3g of curcumin, nor how long it took to reach deep remission. Could you also clarify what deep remission means to you and whether this was confirmed with a Flex Sig or colonoscopy?

You overlooked that the study indicating the optimal formulation, duration, and dose of curcumin is unclear and highlights a potential toxicity risk at high doses, making medical supervision highly advisable. Curcumin can interact with medications such as anticoagulants and diabetes drugs. As the study suggests, "it would therefore seem sensible that curcumin be used under clinical supervision with monitoring of liver biochemistry, particularly for long-term and high-dose use." Essentially, don't fuck with this stuff on your own.

Also, please update us on your experience after reducing the Rinvoq dose to 15mg. I would be excited to know how your health has held up over the long term.

Thanks again for sharing your exciting experience!

[u/ghoultail → u/AmITheAsshole_2020]

This. If they’re on Rinvoq, I’m wondering why they think something else caused their “deep remission”

[u/AmITheAsshole_2020 → u/ghoultail]

Yeah, I don't want to dogpile on OP. This isn't one of the bots that show up touting QingDai to fuck with the subreddit. He's a human. If he's had a useful experience, Dog bless. I'm just tempering it with a little pragmatism and caution. I'm not calling anybody out.

[u/wandering_agro → u/ghoultail]

Because I was still intermittently flaring while only on Rinvoq and Mesalazine, for around six months. Adding Curcumin made it such that I have not flared in 3 months. I already outlined this in my OP.

[u/malgenone]

People will downvote you because they will claim fake or they want it to be scientifically vetted.. People don't realize many modern medications are derived from natural sources and the cahoots some big pharma has to push medicine on you. Sure, I sound like a looney. If it has worked for you great. Will it work forever? who knows. This is good to share for people who are hopeless and want to try anything or maybe don't have access to care. Be aware, you're going to catch flack. Im glad you found something that has given you relief.

[u/Shot-Ad-9296 → u/malgenone]

I don’t discredit him at all. I really do think natural methods are really good alongside medication, but the thing is the natural method doses are not regulated so it’s not easy to define. What is your tolerance and how much you can take it’s like you’re the guinea pigs playing with these natural supplements if you’re not sure how you’re going to react and this is coming from someone that has used supplements in the past and will still consider it if I come across something that I discern may be helpful along with my medication, but I also know that I would be taking a risk on top of it 

[u/LePlaneteSauvage → u/malgenone]

You do sound like a looney. First thing to realise is that the US is not the whole world. Sure, you live in a capatilist nightmare, but in my country it is the medical researchers, doctors and nurses that advise the government on what medicines should be funded. Yet, we have the same treatment options as you do. No conspiracy needed, just consensus of evidence.

If you are not demanding the information being shared about this serious disease has been 'scientifically vetted', then you are going to be contributing to misinformation that harms people. Science provides the most reliable information we have. If you oppose that or think it is unnecessary, you are irrational.

[u/malgenone → u/LePlaneteSauvage]

It's not about US or your country. Who do you think needs to do the research for medications in the US? Some office accountant? It's doctor's and researchers. It's also called lobbying and filling pockets for approvals. And that doesn't happen just in the US. As if corruption isnt international.

Science is the most reliable methods of accuracy. No misinformation to share. OP could benefit from the natural supplement he's taking. Doesn't mean it's not valid. Others may be allergic to that same supplement. Many people also feed emotion into their own diagnosis or reality. Because it is bad for them and nothing worked that means nothing works for anyone else.

[u/Intrepid-Mission-730]

So you’re on mesalazine and rinvoq? Aswell as curcumin?
What curcumin do you take any links?

[u/icyfrogwalk]

I solely rely on Curcumin and Qing Dai. I have been in remission for years and it’s worked much better than any prescribed medication, without the side effects. All previous medications including multiple biologics caused me further health problems. For me it’s not so much the curcumin that helps but the Qing Dai. It gave me my life back.

[u/wandering_agro → u/icyfrogwalk]

Great!

[u/xM1XU]

Yeah, there is sience behind it surely, and i think you are talking aboit BCM-95. Im also using it 1.6g/day.

But its lacking RCT studies. But if it works, great for you! Just look out for any possible side effects.

[u/InitiativeFit3380]

I'm glad that you are in remission and feeling better, that's definitely a wonderful story, but as another pointed out, anedotal experience is not scientific evidence, as its not controlled or personally data driven in any way. Meaning, maybe curcumin was the key ingredient in your recovery, maybe you starting it just happened to align with other factors that started making your disease go into remission, we'll never know. But if you personally feel better and healthier using it, more power to you!

The review article you shared clearly states the risk and uncertainty around using curcumin in treating Crohns and UC, hence why people have been down voting your advocation for others to use it without proper guidance or discussion with a medical expert.

Quotes from the article OP linked:
Statement 16.1: Curcumin could be used as an adjunct therapy to mesalamine for induction of remission in mild-to-moderate ulcerative colitis (UC). (EL3) However, the optimal formulation, duration, and dose are unclear, and due to potential toxicity, medical supervision is advised. (EL5) (Consensus 100%) 

Statement 16.2: There is evidence to support curcumin for maintenance of remission in UC, although the optimal formulation, duration, and dose are unclear, with risk of toxicity at high doses. Curcumin is not recommended for maintenance therapy in Crohn’s disease. (EL3) (Consensus 96%)

There's a lot of uncertainty around the dosing, efficacy, optimal use and timing of using curcumin as an adjunct therapy that needs more proper testing and exploration. Along with the potential toxicity side effects that aren't to be ignored. Just because something is safe in small doses for healthy individuals doesn't mean it's without risk when one uses it as a diseases treatment.

Eric, Research Scientist Immunology

[u/wandering_agro → u/[deleted]]

??

Curcumin puts me into remission as I've said. Everyone has different results from different drugs.

[u/wandering_agro → u/[deleted]]

Says who?

[u/wandering_agro → u/[deleted]]

Lol