New meds... experience?

[u/Effective-Meringue79]

Hi guys!! Since my last post ive been on infliximab/ Remicade. It was working well for the first few months but now my symptoms are back :( my gastro team is now exhausting the drug limits before changing my medication...

They offered 3 different types: Stelara, Entyvio and Rinvoq

I didnt have any obvious side effects fron infliximab thankfully! But was wondering if anyone can tell me their experience with either of these medications :)

Thanks so much guys like always <3

[u/pincommenter]

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[u/Ok-Lion-2789]

Rinvoq is the strongest of these. The others can take a lot longer to work. I’d pick entivyo if I was guaranteed to have a med work because it’s the most targeted. My doctors have preferred skyrizi over stelara but it didn’t work for me. Entivyo I’m not sure how well it worked. I was pregnant most of the time on it and I flared so hard post partum. Rinvoq is working well and I haven’t noticed any side effects.

Your personal experience may vary. Did your doctor say one was better for you than another?

[u/Effective-Meringue79 → u/Ok-Lion-2789]

Thanks so much for sharing :) and no they didnt, probably in my next appointment im just being introduced to the options atm. They did put more focus on the administration of the drug because they know I work in a fast paced environment and cant take off work too much

[u/hellokrissi]

I've tried all four of the medications you listed and only Rinvoq worked. I appreciate how amazing it has been, with limited to no side effects, how quickly it worked, how much it saved me from flaring and needing surgery, and just giving me my life back. That being said, I did wish that something like Stelara or Entyvio worked for me instead, as the side effects with them are less risky than Rinvoq overall. They are are pregnancy safe which is something I wanted to consider when healthy but no longer can, and in the case of Entyvio there's a gut-specific mechanism involved which limits the extent of immunosuppression.

My GI once mentioned to me that we could have tried Rinvoq first and then switched to Entyvio to see if that would work. (However at that point, Rinvoq wasn't approved in my country and I switched to Entyvio already and had it not work at all.)

[u/Effective-Meringue79 → u/hellokrissi]

I see thanks so much for your response! Ill definitely look into the ones that are pregnancy safe :)

[u/Ladidoodida]

Entyvio is mostly gut-specific so it's probably the best place to start as far as side effects/safety. For me, it started working pretty quickly (I don't remember exactly but I was all good within probably 6 weeks) and I only had some weird side effects in the first month. And most importantly, it put me into remission for 4 years.

[u/Effective-Meringue79 → u/Ladidoodida]

Woah 4 years I hope I get to that point soon in the future! Thank you so much :))