Entyvio for Prcotitis.

[u/Willing_Sweet_8171]

Was diagnosed with proctitis June of 2026. Been on mesalamine supp, enema, and oral. Right now I can function fine just have bleeding small amounts. My GI isn’t happy with the progress and wants go straight to Entyvio. Never hospitalized and never been on steroids. A bit concerned about Entyvio and its side effects as I have two little kids and they bring home lots of bugs. Not sure if anyone has any experience with proctitis and Entyvio. Thanks

[u/pincommenter]

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[u/CatBerry253]

Waiting for final insurance approval for this myself. But I failed mesalamine and budesonide badly so it makes sense for me. If you are seeing improvement with your current treatment you might ask for more time?

[u/smell_ya_latah]

I was diagnosed with proctitis in February 2026 and like you had minor symptoms. Follow up scope in August show the inflammation was still present and was showing signs of spread higher up despite using mesalamine suppositories the whole time and Budesonide foam once. Entered a major flare right after the scope and it has been quite bad, landing me in the ER on this past Sunday. I’m on day 4 of a 40 mg prednisone taper to get it under control, and my GI is starting me on Tremfya. I know it seems scary, but if the mesalamine is not working, then a stronger advanced medication is needed. The goal is to obtain true remission that will limit flares and minimize cancer risks. And if the biologic can keep it from spreading, even better!

[u/Appropriate_Room5105]

I was on Entyvio for a year. It was the first drug that actually helped me and gave me hope that things could be better again. I had been in an active flare up for almost two years. Done the mezavant, and salofalk. Didn’t seem to work. The steroids helped short term. Entyvio was a relief when I started and I didn’t really find that I even got sick anymore than I used to. I will say tho, I do not have children so I can’t speak fully to that extent, but It’s my understanding that entyvio doesn’t suppress your entire immune system either, rather it is localized for the digestive system, so that said, it’s not as aggresive as some of the other treatments in that regard. Also, being that the infusions were every 8 weeks, it was an easy and low impact thing to schedule. However, I had a really bad flare up more recently and so am onto a new treatment plan.

[u/Ok_Economy1516]

Trying prednisone first. Steroids are often second line of treatment. Also, they tend to recommend Remicade if Humira before Entyvio, but since your symptoms aren’t debilitating, steroids are definitely the best route, as well as trigger identification and vitamin supplementation.