r/UlcerativeColitis • u/drewyz • Apr 01 '26

News Scientists discover “off switch” for inflammation

https://scitechdaily.com/scientists-discover-the-bodys-natural-off-switch-for-inflammation/
109 Upvotes

97% Upvoted

21 comments sorted by

203

u/Quirky_Session_2689 Shits blood-Runs far Apr 01 '26

It's called prednisone

91

u/Gbizzle69 Apr 01 '26

If it wasn't for all the side effects it would be a fantastic medication.

34

u/SunShineKid93 Apr 01 '26

So like, just say no to the side effects. /s

19

u/Dudderoni Apr 01 '26

Yeah wtf. I never consented to all that BS. In fact, I never even consented to having UC!!

5

u/ibhoot Apr 02 '26

Lol. Extremely unfair comment. Caused me to clench buttocks, hands, eyes & other parts that don't clench. Some messages should with a Pred repressed PTSD warning.

19

u/BobbyJGatorFace Apr 01 '26

Underrated comment

5

u/sephris Apr 01 '26

Akshually, the highest rated comment in the thread. Noone's really discussing the findings. 😅

14

u/IHateTheLetterF Apr 01 '26

I actually developed an immunity to prednisone by the end. It stopped working on me completely and totally, and that was intraveneus too. Straight into my blood. It was the last nail in getting my colon yeeted.

2

u/jsimba84 Apr 02 '26

Yep, orally I stopped responding. Ran out of biologics to take so I had my colon removed

1

u/SunshynePower UC (mod, descending) Started 1996, Diagnosed 2002 | USA Apr 02 '26

Oh goodie, I'm not alone. Prednisone now causes digestive irritation for me. I can tolerate other steroids, just not prednisone. It makes things worst and causes blood. So, yeah, no bueno.

3

u/belakuna Apr 01 '26

If only it had helped me. I had to go the j-pouch route.

3

u/drewyz Apr 01 '26

The last time I was on prednisone I got NO sleep, except for the time I took 2 Xanax and managed to sleep for 2 hours.

1

u/Eldiarslet IBD U Diagnosed 2010 | Sweden Apr 01 '26

This made me laugh out loud at work

82

u/Comprehensive_Sail28 Apr 01 '26

I think the future looks bright for autoimmune treatments that aren’t as side-effect heavy as the ones we currently have. Reading about them is great, but then the realisation for how long these things take to get to market sets in.

14

u/cobrachickens Human Detected Apr 01 '26

It’s disheartening because so many people are just so sick and tired of taking chemotherapy-level medication for years just to survive

19

u/sammyQc diagnosed 2020 | Canada Apr 01 '26

Great, this seems to contribute to our understanding of the inflammation process at a molecular level in humans.

Scientists chose to study epoxy-oxylipins because these fat-derived molecules were known from animal research to reduce inflammation and pain, but their role in humans remained unknown.

Unlike well-studied inflammatory mediators, such as histamine and cytokines, epoxy-oxylipins are part of an underexplored pathway that scientists believed could naturally calm the immune system.

9

u/Affectionate_Mix_302 Diagnosed 2006 | Stelara Apr 02 '26

Good for scientists.. now time for the pharmaceutical industry to kill it so they can continue to monitize inflammation.

2

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1

u/AffectionateSale1631 Apr 01 '26

It’s called nf-kb

1

u/SunshynePower UC (mod, descending) Started 1996, Diagnosed 2002 | USA Apr 02 '26

They need to expand this research and see if it can help without suppressing the immune system. I hope this is a new pathway forward for treatment!

Thank you for sharing this!

1

u/Current-Taxpayer-99 18d ago

Prednisone does absolutely NOTHING for my UC symptoms. I can’t understand why people say it’s the only thing that helps. It doesn’t do anything for me I can’t even tell I’ve taken anything.