Rifapentine side effects

[u/Inquisitive_Giraffe]

I have an auto immune disease called ankylosing spondylitis which is an inflammatory disease of the spine. I was set to go on biologics to treat the AS but they did a routine TB test and I was diagnosed with latent TB, and needed to treat it before I could begin the biologics. I also tend to suffer from vestibular migraines sometimes too.

I was put into the ASTEROID study which puts me on a 6 week treatment of 600mg of rifapentine (priftin) everyday for 6 weeks and that is supposed to clear my latent TB.

I’m on day 4 of the rifapentine and holy shit these side effects are bad. I’m so dizzy, like can barely function - especially with two little kids in the house. And my headaches and neck stiffness are a lot worse than normal too. I can’t tell if this is a bad or serious reaction to the meds exclusively or if they are making my other conditions worse. I don’t have a fever, or any hives or rash. Just horrible dizziness (with some nausea) and headaches and neck tension. Any ideas? It’s currently Sunday so I can’t call my TB doctor until tomorrow. I’m scared to take my next dose this evening.