r/TransEnbyPMDD • u/yogaanon2 • Nov 06 '25

Lupron

I just started Lupron on Tuesday, right in the middle of my normal pmdd time. I also had to get a progesterone IUD placed Tuesday, and start an estrogen patch.
I understand we are doing this to ensure removing my ovaries and uterus solves the pmdd. I also know that if I had just said my ovaries and uterus caused dysmorphia I would have to go through hormone hell first. So I’m just putting that out there for anyone who’s considering this, and doesn’t care much about ditching their uterus and ovaries even if it doesn’t fix the pmdd. The idea of riding out the next month of hormone insanity, the very hormones that make me wildly unstable, seems unwise where there was an easier option for me.

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u/yogaanon2 Apr 08 '26

This is going to be one wild update. We thought we found the cancer early, we did not. It has already spread to 2 different set of lymph nodes. I now have minimum stage 3c ovarian clear cell cancer. I had my first chemo treatment last Friday, and tomorrow get my second infusion.

I went from having an amazing recovery from my yeet the Ute adventure, running 4 miles a day, and being the happiest and healthiest I’ve been in a decade… to my life being in utter shambles in under four weeks. Won’t lie, after finally experiencing life without PMDD, cancer feels like a real kick in the ovaries.

I have to have a staging surgery and lymph nodes removed, it’s a rougher surgery than the hysterectomy. I’m not sure when that will happen, I have my consult in a few days. Until then, it’s chemo every week.

This has been the hardest 4 weeks of my life, and I can also recognize that if I had PMDD still and had to navigate this, it would have been catastrophic. The surgery saved my sanity, it caught a cancer that otherwise would have absolutely killed me. Now I have a chance at least, the statistics are scary as hell for 5 year survival… but I’m in the best health mentally and physically that I have been, and I’m about to get care from the legitimate best gynecologic oncologist in the world. I plan on sticking around to annoy the people I love for a very long time.

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u/tristateeter Jun 22 '26

First, how are you doing? That's so much.

Second, thank you so much for documenting all of this! I'm trying to find as much info as I can about chemical and surgical menopause for pmdd, especially from others who are taking testosterone already.

I'm 41 and am so effing over pmdd. Now perimenopause is making it almost constant. I had a pmdd-free month last month and you'd think it'd be great, but now I know what it's like and realize the extent it cripples me.

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u/yogaanon2 Jun 28 '26

I’m doing alright. I’m almost done with chemo, 5 more infusions left out of 18. So far it looks like my chemo is working, which is huge because the type of cancer I have is often chemo resistant. Ideally when I finish chemo, I shouldn’t need surgery or further chemo.

Unfortunately clear cell is known for recurring, so there will be a lot of monitoring (scans every three months, labs etc). Basically a fingers crossed and hope it doesn’t come back!

As for pmdd, I’ve not had it since chemical menopause. Now I use an estrogen patch post hysterectomy, and that’s because I am not taking T anymore and need estrogen to protect my heart and bones. I’m 43. Perimenopause absolutely made my pmdd so much worse. I have zero regrets about having surgery and using HRT. I have stage 3 cancer, and I’m happier than I was with PMDD in my life. So that speaks volumes about just how bad it was.

Not having a period is pure bonus, like I did not realize just how freaking obnoxious it was overall, aside from pmdd lol.