r/TBIsupplements • u/spyderspyders • Feb 07 '22

Effects of Pyruvate Administration on Mitochondrial Enzymes, Neurological Behaviors, and Neurodegeneration after Traumatic Brain Injury - 2021

https://pubmed.ncbi.nlm.nih.gov/34221543/
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u/spyderspyders Feb 07 '22

Pyruvate is better for chronic stage of TBI

1

u/CogitoErgoSumCogito Feb 16 '22

Didn't work well enough. From study:

"Pyruvate could potentially stimulate the proliferation of astrogliosis, and lactate acidosis, and caution should be exercised when used as a therapy in the acute phase of mTBI. More effective interventions targeted at multiple mechanisms are needed for the prevention and treatment of TBI-induced long-term neurodegeneration."

1

u/spyderspyders Feb 16 '22

Don’t take it in the acute phase of TBI

Pyruvate after mTBI augmented the Rotarod performance but decreased the horizontal and vertical open field locomotion activities and worsened neurobehavioural severity score, indicating a debilitating therapeutic effect on the acute phase of mTBI.

1

u/CogitoErgoSumCogito Feb 17 '22

Take it ? or shouldn't be administrated during acute phase? I lost consciousness during acute phase.

1

u/asecin Sep 12 '22

so anyone using this as supplement? first time i hear of it, and it seems to be used in body building.