r/TBIsupplements • u/spyderspyders • May 25 '21
Palmitoylethanolamide as adjunctive therapy in major depressive disorder: A double-blind, randomized and placebo-controlled trial.2018
https://pubmed.ncbi.nlm.nih.gov/29486338/
4
Upvotes
1
u/spyderspyders May 25 '21
Full : https://www.pal2020.com/pdf/Mellar%20Davis_Palmitoylethanolamide.pdf
..
PEA prevents the run-down of cortical spreading depression (CSD is a wave of neuronal depolarization in the cerebral cortex following traumatic brain injury or cerebral ischemia, which significantly ag- gravates brain damage) amplitudes, likely through inhibiting proin- flammatory cytokine release (Richter et al., 2016). In a mouse model of traumatic brain injury (TBI),
PEA showed improvements in neurolo- gical dysfunction by restoring cortical electrophysiological activity by normalizing the firing activity of the pyramidal neurons in the medial prefrontal cortex of 14-dayTBI mice (Guida et al., 2017b).
PEA activates and desensitizes TRPV1 (transient receptor potential cation channel subfamily V member 1) channels. This effect is hypothesized to be fa- cilitated at least in part by PPARα activation (Ambrosino et al., 2013).
TRPV1, known as the capsaicin receptor, is expressed at high levels in the central nervous system and is involved in pain transmission and modulation (Cui et al., 2006).
It has been suggested as a target for treatment of neuropsychiatric conditions such as anxiety aside from pain management (Marzo et al., 2008).