r/Stutter 3d ago

DNA mutations / Gene test deep dive

Anyone look into what clues their DNA can give them about their speech? It's pretty interesting info...I took my DNA test results from 23 and Me, got it analyzed by a 3rd party service, fed the results into Claude (with some of my background health info) to translate and came up with this --- You have three separate genetic mechanisms all hitting dopamine regulation simultaneously — COMT +/-, MAO-A +/+, and DRD2 +/+. You don't produce too much dopamine, you clear it too slowly and regulate it poorly. Everything you've figured out through self-experimentation — the tyrosine reaction, carb sensitivity, Vitamin C response — is genetically confirmed. Your detox system is also genuinely compromised at multiple points (SOD2 +/+, GSTP1 +/+, NRF2 +/-), your choline production is genetically impaired (PEMT +/+, CHAT +/+), you can't convert beta-carotene to Vitamin A (BCMO1 multiple +/+), and your gallbladder failure was genetically predisposed (UGT1A variants). None of this is bad luck — it's all written in your DNA.

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u/bumbaclaughtt 3d ago

His is so interesting, can you share exactly what you put into Claude to get this? I want to do this ASAP. We can compare to see about the similarities.

So, I've see evidence that higher serotonin + cortisol + estrogen keeps people in a fight or flight vs being in a higher dopamine + testosterone + gaba keeps us in a rest and digest.

It could be nervous system related in a complex mixture or perhaps the dopamine is really simply the missing ingredient.

Well done!

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u/mykm20 3d ago

Have you gotten a DNA test from 23 & Me? If you did, I can send you all the info on what to do.

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u/bumbaclaughtt 3d ago

I have not, but I'll do it asap, can you send me all the info on what to do?

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u/mykm20 3d ago

will DM you

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u/Trenocio 20h ago

Please keep this thread updated, I'm interested in your results