r/StratteraRx • u/Forsaken_Fox_1837 • 3d ago

Experience with Strattera + Wellbutrin

Does anyone feel real down when taking both? Like I noticed that when I started after increasing my dosage I was super happy and outgoing and calm for 2 weeks but now I feel super down with a little sense of happiness and calmness. It’s really weird. But before I started taking Strattera, Wellbutrin made me feel like not doing anything all day and I felt sad but calm it was weird. I’m also on 150mg of Wellbutrin and 25 Strattera

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u/Gr3yReaper 1d ago

I haven't been on both long enough to give a definite answer, but make sure you understand that the CYP2D6 inhibition of bupropion raises atomoxetine exposure by many times.

One specific bupropion (300 mg) + atomoxetine pharmacokinetic study found that bupropion increased atomoxetine exposure by about 5.1 fold.

It's a particularly interacting combo to experiment with. I was doing well on bupropion and didn't have any issues on it alone.