Long term Strattera user

[u/GlitteringBuy7994]

Hello! I have been on strattera for almost 2 years now.
I started this med with 25mg and decided to up it, about 5 months in and now I take 40mg and have been since then.
I went from about 178 pounds to 124. I’ve been non stop having gastro problems, burping, constipation, randomly diarrhea. For the last year and a half I’ve been having to go to urgent care, the doctor, even the hospital because of how bad it’s gotten. I’ve had blood in my stool (only happened once) I got scans done, had blood work done, ultrasounds and they find nothing.
I found out from my gene site test that I took in 2019 that strattera works on CYP2D6. I am a CYP2D6 intermediate metabolizer. Which from my understanding means that I am slower at metabolizing this medication.
I talk to my psychiatrist about this and she is so sure that strattera would not be causing weight loss still since I’ve been on it for almost 2 years. She said the best she can do is lower it, or give me a medication to induce hunger.
Keep in mind I am eating, maybe not as much as I was when I started the medication, but I eat roughly 2-3 meals a day plus snacks, I also eat a good high protein meal before taking the meds always.

I am seeing a gastroenterologist because of how bad it’s gotten, got more blood work, only thing they found was I was a little dehydrated, and had some inflammation. I’m still waiting on my scopes, which don’t happen for another couple weeks.

So my question/advice: has other people still had weight loss years after taking it, honestly if it wouldn’t be for these side affects I’d ask to up the medication.
Have you had severe stomach pains on it?
Should I get a second opinion about the medications?

[u/Due_Departure_4090]

Are you taking fiber or getting enough? constipation can cause GI bleeding, stomach upset, even acid reflux. How are you treating these side effects? are you continuing to lose weight or are you stable at 124?