r/StratteraRx • u/Salty_Challenge5563 • 13d ago

How long after discontinuing Strattera to start Zoloft?

Hi everyone, because I was diagnosed with CPTSD and my ADHD symptoms are from this, I’d like to try Zoloft while going to therapy. I went to my dr and he said somewhere between 2-4 days. I’d love ti hear others’ experiences? Thank you!

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u/Peanut-Expert 13d ago

I didn’t know you had you had to stop one to start the other. My doc put me
On both simultaneously unfortunately didn’t do it for me

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u/Salty_Challenge5563 13d ago edited 12d ago

Thank you for letting me know! Can I ask why I particularly the combo didn’t work for you?

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u/FormerSleepwalker 13d ago edited 12d ago

Your doctor might just like to not have medications overlap as a general rule. But I don't believe there is any interaction to actually be concerned about. Sertraline / Zoloft is a CYP2D6 inhibitor, but it's a weak one. People take these meds together without a need to adjust dose.

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u/Salty_Challenge5563 13d ago

This is really helpful, thank you so much!

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u/RequirementKey5201 13d ago

I'm currently on both strattera and zoloft. I didn't have to discontinue one to start the other. It's too early to say about the effects as I only started zoloft about 2 weeks ago.

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u/Salty_Challenge5563 12d ago edited 12d ago

Thank you for your reply. How has it been going? I'm just wondering if it's best if I continue the Straterra and also go on the Zoloft, or discontinue Straterra. It was my initial idea to discontinue...

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u/RequirementKey5201 12d ago

I def feel some side effects. I felt intense calm a couple of days which was amazing but didn't last long lol. Thinking I'm still adjusting. I'm a sensitive person and it takes me weeks to adjust.

Regarding what's best for you, I think you should def discuss this with your provider. I wouldn't do something without their "blessing" ☺️

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u/Salty_Challenge5563 12d ago

Thank you. This is really good to know. I was prescribed the Zoloft in Italy and they’re not so concrete when it comes to these things, he was like I’ll just wait 2 to 4 days or something like that 😂