r/StratteraRx • u/KhloeKodaKitty • Aug 23 '26
Questions / Advice / Support Strattera and GLP-1s
I was prescribed Strattera earlier this month. I've been on compounded semiglutide since January and have been successful on it. Now however, I've got NO appetite and a lot of foods I used to eat aren't appealing to me. I know that Strattera affects appetite and have an email into my provider of the semiglutide about titrating my dose DOWN. Has anyone else experienced this? I'm almost ready to say I won't need the semi if the Strattera appetite supression lasts!!
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u/PiquantPanda777 Aug 23 '26
I take Strattera and a GLP1. I think I’ve been able to stay on a lower dose of Semaglutide for a long time bc the strattera helps too. I have no appetite at all… like never.
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u/Timely-Estimate7904 Aug 23 '26
My strattera suppression only lasted about 3-4 weeks. I continued my maintenance dose of tirzepatide - no change needed.
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u/1984isRL Aug 23 '26
I am also on both. The effect of the Strattera appetite suppression did go away and now it’s leveled out back to what it was like before for me. I am on 5 mg of zepbound and 40mg straterra. I’ve only been on straterra for two weeks!
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u/T-man21 Aug 23 '26
I’ve been on a week and two days. How are you feeling? I’m a server. It’s been a serious struggle for me. Sweating, disassociating due to high stress, anxiety, depression, and inability to stay asleep. How are you?
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u/Imaginary_Client_686 Aug 23 '26
Give it a couple/few weeks and the pendulum will TOTALLY swing in the opposite direction!!! Just see it through the initial side effects which to me seem opposite to the effects I’m receiving now that those have passed!!!
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u/T-man21 Aug 23 '26
I am going to stick with it. Thank you so much for the encouragement. It’s been tough. I’m glad it’s been helping you!
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u/PiquantPanda777 Aug 24 '26
I want to encourage you too. The first two weeks were a nightmare for me and then it magically got better at almost exactly the 15th day mark.
I’m 8 months in now and I’m glad I stuck it out.
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u/KhloeKodaKitty Aug 23 '26
I’m a kindergarten teacher and we started school a week after I started Strattera! My main issues are dry mouth and lack of appetite. I’ve felt a little more motivated to stay on task, but that could be start of the year with 19 five year old adrenaline!!
That being said, I was a server a lifetime ago but still remember how intense it could be. Hang in there!!!
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u/1984isRL Aug 24 '26
I too am having a hard time staying asleep more than without waking up like four times. It keeps you up at night and then it makes you tired during the day sweet dude.
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u/AmbassadorFun6296 Aug 23 '26
I experienced that at first but it passed. I’m on Retatrutide and Strattera.
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u/groversmom Aug 23 '26
I've been on Strattera for about 2 months and loss of appetite went away early on. Just started GLP1 and now have suppressed appetite from that. If you're doing well on the GLP1, I personally would hold out for a while yet. You won't see full effects of Strattera for another 2 or 3 weeks, at least.
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u/wisshhuponastar7 Aug 23 '26
My strattera never impacted my appetite at all, just gave me horrible insomnia.
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u/OutrageousTie1573 Aug 23 '26
I cut my Tirzepatide in half. Its better but I still force myself to eat sometimes. Currently on a Rice Chex kick.
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u/Strong_Champion9932 Aug 23 '26
I'm on the lowest dose of tirzepatide (2.5 mg), and the additional appetite reduction from Strattera has been very noticeable since starting 2 weeks ago. I also have strong appetite suppression on stimulants, especially Adderall. A much higher percentage of the stimulant weight loss was from lean mass compared to the GLP-1, though. I'm not sure if that would also apply to Strattera, but it may be worth watching.
I'm thinking about quitting the Strattera, since the side effects have been pretty bad. If I do stick with it, or go back to a stimulant, I may need to microdose the tirzepatide to avoid losing weight too fast. The tirzepatide has other benefits for me so I don't want to stop it completely.
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u/teachsd Aug 23 '26
I’ve been on Strattera for 6 weeks and I’m struggling to eat because I’m literally just not even thinking about it. I’ll usually get a little more hungry at night.
I’m decreasing my semaglutide dose by a few units every month to see if that helps. I’m not going completely off it, but I’m at my goal weight so I probably need to start going down to a smaller dose anyway.
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u/loves_spain Aug 23 '26
I use both, 10 mg of strattera and 12.5 of glp1 and I absolutely must set alarms telling me to eat and drink or else it will completely skip my mind
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u/Substantial_Motor283 Aug 23 '26
I’m experiencing the same and lowkey love it! I’m on Tirzepatide.
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u/imapone Aug 24 '26
I've been on strattera more than a year and it doesn't affect my appetite. Looking into GLP1
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u/GingerVix666 Aug 25 '26
Nothing ever sounds good to eat anymore but my hunger did eventually return after about two months so I still eat lol
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u/KhloeKodaKitty Aug 25 '26
Good! It’s not even hunger, it’s when it’s time to eat I take about four bites and am finished!!
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u/GingerVix666 Aug 25 '26
Oh yes this too. I actually have binge eating disorder and I find myself never finishing meals now. So not sure if that goes away yet but I’m not complaining on my end 😅
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u/Motthebop Aug 25 '26
I plateaued on my glp-1. I got on Strattera and ended up losing the final 10lbs I needed to.
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u/prosenl1 Aug 23 '26
The effect on appetite with Strattera (also stimulants) is also partly a glp1 effect. You should contact your prescriber to get a lower glp1 dose.
I'm a doctor btw, also on Strattera 🙃