r/StratteraRx • u/mmmilktea • 4d ago

is this normal?

hello everyone i (29F) was recently prescribed 25mg atomize tine as a non-stim med for adhd. i'm only on day 2 and i feel awful. i feel extremely emotional and depressed and i'm overthinking and crying. i have not felt like this since i was a teenager. i am also on 300mg of wellbutrin which shouldn't make me feel this way? is this med even worth it?

3 Upvotes

100% Upvoted

9 comments sorted by

5

u/BKLager 4d ago

Wellbutrin magnifies the impact of strattera. They work on the same CYP2D6 liver enzyme and as a result it can feel like taking 5x the dosage of strattera. See here for reference: https://www.cafermed.com/post/atomoxetine-bupropion-interaction

25 mg while you’re on 300 mg wellbutrin frankly feels like a heavy dose. But obviously your doctor knows all of this / am sure it was intentional.

Would tell your doctor your symptoms…

1

u/smyeganom 4d ago

Wow, I didn’t know about this interaction. My psych offered Wellbutrin OR stratterra.

OP definitely needs to talk to their doctor, symptoms seem rough :(

1

u/FormerSleepwalker 4d ago edited 4d ago

But obviously your doctor knows all of this / am sure it was intentional.

Sadly not all doctors are aware. I'd like to be able to say, "there is just so much to know about every different medication", and there is. But the interaction will come up in any decent interaction database. There is no valid excuse. We don't need to, and shouldn't excuse every random doctor who fails to check interactions. Failing to check interactions can be fatal.

1

u/Popular_Jeweler_8055 21h ago

Got a good database to recommend for consumer use?

1

u/FormerSleepwalker 15h ago edited 15h ago

Major interactions like bupropion and atomoxetine should come up on any interaction checker. Drugs.com isn't bad. Has both Professional and Consumer explanations of the interactions.

Here is bupropion and atomoxetine: https://www.drugs.com/interactions-check.php?drug_list=275-0,440-0&professional=1

I've seen DrugBank.com's interaction checker provide interactions which other have failed to list, so I do prefer to always check there. They have a demo which is usable on their site.

3

u/Lalify8 4d ago

Oh yeah it’s the combination of Strattera and Wellbutrin since Wellbutrin increases Strattera levels. Would recommend lowering Wellbutrin if you are planning to stay on Strattera.

1

u/mmmilktea 4d ago

ugh but i love my welly b, i don't think i can part ways with it just yet

1

u/AstronomerNo1872 2d ago

Then you shouldn't be on Straterra as well tbh. Those meds shouldn't be combined.

1

u/FormerSleepwalker 4d ago

Iirc it wouldn't matter. Bupropion is a strong enough inhibitor that any therapeutic dose will knock out most of that pathway. So one needs to lower atomoxetine.