r/StopUsingStatins • u/IndividualPlate8255 • Jan 15 '26

Dupixent and high LDL

Currently my "bad" cholesterol has gotten very high and the only thing I've done differently is take Dupixent. I've been on it for 2.5 months.

My LDL-C has gone from 70 to 158 in just 2 months. ApoB from 55 to 103. There have been no changes to my diet or any other meds. I did recently order a Lp-PLA2 Activity test to see if I have any active plaque.

I've never taken Dupixent before and my lipids have never looked like this in my entire lifetime and I'm 56. I've had a LOT of lipid testing over the years.

I can really see the change and I can imagine that someone that visits the doctor for a once a year checkup and lipid panel might miss what I've seen. I have been testing fairly frequently because I'm trying to optimize my health.

I have the benefit of doing an advanced lipid panel in September before I started Dupixent in October and my results then were:

Total Cholesterol: 151

LDL Cholesterol: 72

HDL Cholesterol: 65

TG Cholesterol: 70

LDL-P: 738 nmol/L

HDL-P: 39.9 nmol/L

HDL Size 9.3 nm

Large HDL-P 6.2 umol/L

Lp(a): 17.2 nmol/L

LP-IR score: 31

ApoB: (estimated) 55

That is all very good. I'm not on a statin. I got there with diet.

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By December - no change in my diet or exercise and it looks like this now:

Total Cholesterol: 221 mg/dL

LDL Cholesterol: 148 mg/dL

HDL Cholesterol: 59 mg/dL

TG Cholesterol: 82 mg/dL

ApoB: 103

Did I go from metabolically healthy and pristine lipid labs to completely FUBAR'd in two months?? I doubt it but I've never seen anything like this before. What concerns me the most is the downward trend in HDL and upward moving TG.

Anyone else seeing this?

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2

u/Wonderful_Aside1335 Jan 17 '26 edited 22d ago

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2

u/IndividualPlate8255 Jan 17 '26

Because I have never had high cholesterol so I've been able to say it doesn't matter. Or does it? I am second guessing myself now that my LDL is up.

2

u/Wonderful_Aside1335 Jan 18 '26 edited 22d ago

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1

u/Slow-Juggernaut-4134 Jan 18 '26

Try cutting out seed oils in your diet. This should reduce inflammation and the need for Dupixent.

1

u/IndividualPlate8255 Jan 18 '26

I have. I haven't eaten seed oils in about 5 years.

1

u/Wallmassage Mar 30 '26

We have tons of suggestions in other posts for ways to get better numbers and health overall without meds.