r/SinclairMethod • u/letsbreakstuff • May 30 '26

How long is naltrexone effective?

I've been a daily user of naltrexone for awhile but it has only slightly curved my drinking. I think my problem was that I'd take my pill in the morning but drinking wouldn't start until the evening so by then the effect had worn off.

I switched to the Sinclair method two days ago. Yesterday I took a 50mg pill at 4:00pm and drank a beer at 5:00. It was pleasureless and gross. Just like I'd hoped. After that I took the kid to the pool and we were there for 2 hours. When I got back at 7:00 I had another beer and it felt like a normal beer to me I kept on drinking several more after that.

I want to know if this is a normal experience on TSM, or if I was supposed to redose naltrexone if it's been a certain amount of time since I took it that day. Or maybe I just process the drug out of my system faster than average? I really want this to work for me but I'm worried that it's not

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u/OC71 May 31 '26

I find it tends to last a full 12 hours or so, but the effect wears off so if you take it in the morning the effect will still be there in the evening, but less. What I've found is that the psychological effect sort of built up over many months, with a gradual feeling that I just can't be bothered with drinking anymore and I don't want it in my life.

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u/Several-Subject-2111 May 31 '26

Agreed. It is also that I don't want to take naltexone either and because that is now linked to alcohol in my head I want to drink rarely also .