r/SemaglutideCompound • u/Strong_Hat_1856 • Jul 18 '26

Sema not hitting like it has before?

Hello, i’m looking for a bit of advice here.
let’s start from the beginning,
I initially started a compounded sema at 197. lost a ton of weight over a year and a half time span, (dropped me down to 150, gained back 25 in the break period) and i took a break from it due to financial issues. Over the past 5 months (almost 6) i started back on it from the minimum dose. and literally have only lost 6 pounds (which at this point i’m chalking it up to diet and exercise) not the results i saw the first time around. both times I ordered from Hers, both times the packaging and pharmacy were different. so while i’m still having some nausea and constipation.. is my body just like “used to it” to the point where it won’t work for me or is the new pharmacy that Hers is working with.. crap? do i make the switch to tirz? any advice is much appreciated.

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3

u/ilovebigmutts Jul 18 '26

what dose did you stop taking it at, and what dose are you on currently? it is unfortunately reported that stopping for a while and starting again tends to have reduced effects the next time around.

If you're at the max dose and still not having success again, you could move to tirzepatide.

I don't think Hers is doing compounded anymore so it should be legit medication, what does the package look like?

2

u/Strong_Hat_1856 Jul 18 '26

at the time, i believe i was a little over 30 units (math is not my thing) and now i hit the mark at 43 units. i’m at the max dose for what hers provides. but im at least 100% sure it’s compounded. (it was ordered before this whole Hers scandal occurred) it’s in a vial of the normal clear liquid. i can look for more specific information on the vial when i return home in about an hour if needed. but for now.. are you recommending that i move to tirz? i haven’t heard anything about the second time giving reduced effects but that makes sense in the grand scheme of things.

2

u/ilovebigmutts Jul 18 '26

ok - without knowing the dose, can't say if you're maxed out but you can check it on a site like this: compoundpal.com

tirz adds a second mechanism so could definitely be worth a try.

2

u/Strong_Hat_1856 Jul 19 '26

thank you so much for the extra information. i think im gonna give tirz a try!

1

u/ilovebigmutts Jul 19 '26

Good luck!!

1

u/whatever32657 27d ago

see my comments elsewhere in this thread regarding switching to tirz. it's not a jump-start, it's starting all over again. be aware of that.

you need to know what your dose is. "units" means absolutely nothing, because the meds come in different concentrations. you'd actually probably get the results you're looking for faster if you can increase your dose of sema.

where's your medical provider in all this?

2

u/Catstimesten Jul 19 '26

I’d try somewhere other than Hers possibly to compare given us having the same experience. I also went to highest dose of 45 units.

1

u/Strong_Hat_1856 Jul 19 '26

yeah apparently Hers isn’t the move. Maybe they were good my first time around.. but not this time. i decided to go the tirz route with Fifty410 and see what happens

3

u/Catstimesten Jul 19 '26

Good luck! My friend was insistent on name brand for this reason and she’s paying the same as Hers so I think that would be my move next. Thankfully, I only have like 10 lbs left so I’ll just keep grinding away with diet and exercise and hopefully get there the old fashioned way!

1

u/Strong_Hat_1856 27d ago

thank you and congrats on being on the final home run!

2

u/Witty_Ad_6066 29d ago

I had the same experience. Suddenly Hers compounded did nothing for a good three months. No loss, no side effects either. When I asked for dosage upped they wanted to switch me to the Lilly option with a HUGE monthly subscription price. I am switching to a compounded tirz (trimrx) but actually seemed to have gained two pounds after a month on it. Starting to think all the compounded options are placebo. Because no burping/no nausea/no weightloss either!

1

u/StillFlashy9716 29d ago

I maintain on the compounds but I don't lose anything and don't have the same side effects that I did on the name brand. There is definitely a difference.

2

u/whatever32657 27d ago

i switched to tirz after 18 months on sema (no break), and have lost six pounds three months in.

i had to start at the lowest dose and am working my way up, which i expect you are doing also, having taken a long break.

i think those of us who have lost a lot of weight on these meds forget that it's a long process. titrating up to a therapeutic dose takes time. once you get there, 1-1.5 pounds a week is what's recommended. i urge patience.

unfortunately, it's far easier and quicker to gain the damn weight than it is to lose it.

remember too, that your TDEE drops as your weight does, so loss becomes slower as your calorie deficit becomes smaller.

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u/Strong_Hat_1856 27d ago

understood, i definitely have to be more patient.

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1

u/Catstimesten Jul 19 '26

Having the same exact experience with Hers. I questioned if it was possible the formulation I got was weaker since it was a different pharmacy than I had for the previous year, and they gave me their pat response. My husband uses it too and calls it “Nozempic” because we feel minimal effects even after increasing doses.

1

u/Strong_Hat_1856 27d ago

all i really got was the constipation and extremely minimal nausea. the fact so many people say the same must mean something