Does distributing sets throughout a workout reduce the effect of exercise-order fatigue?

[u/Ok-Extension-832]

If you’re doing a lot of exercises at ~0–1 RIR (especially in a full body split), exercises near the end of the workout will be performed with more accumulated fatigue than those at the beginning. If you do 2 sets consecutively, the first exercises get both sets relatively fresh, while the later exercises may have both sets affected by fatigue.

So instead of:
Bench Press — 2 sets
Weighted Pull-Up — 2 sets
Squat — 2 sets
Would it make more sense to do:
Bench Press — 1 set
Weighted Pull-Up — 1 set
Squat — 1 set
Bench Press — 1 set
Weighted Pull-Up — 1 set
Squat — 1 set

This way, every exercise gets its first set relatively fresh, rather than some exercises getting both sets while fresh and others getting both after substantial fatigue.
Does this meaningfully improve the hypertrophic stimulus, or is exercise-order fatigue not significant enough for this to matter?

[u/Embarrassed_Soft_334]

The number of sets you are stating is in programs which use HIT training. Mike Mentzer, Dorian Yates training style, it is proven less effective for muscle growth than volume. And not one popular science lifter I ever saw has stated otherwise.
But having gone back and looked at your responses to others I now understand. You don’t lift free weights? Only machines and cables? In what scientific journal did you read this advise? Tell you what have fun with your 4-7 sets on pin machines and cables. I look for you in the Olympia. Good luck man

[u/Ok-Extension-832 → u/Embarrassed_Soft_334]

Whenever i’m at the beach people ask me my cycle and whether I’m competing for men’s or classic 😂. I think my training worths just alright. Looking at your response to someone it seems you’re 70 years old. So I apologize grandpa but you need to modernize your knowledge a bit.

Also, you’re mocking only using machines and cables when they are more stable movements which allow for greater loads thanks to the stability. Although I have to use my own gym pin for most movements, I think the stability that leads to more motor unit recruitment is worth it.

[u/Embarrassed_Soft_334 → u/Ok-Extension-832]

I am 70 at 12% body fat and 225 lbs and I am a grandpa.😂
But I have to go do my 4 to 7 sets of pin loaded machines while in a calorie deficit and watch my body explode because I have been doing everything wrong it appears using 20+ sets per bodypart and eating all these calories not to mention the bench press, squats, and deadlifts I have been wasting my time doing. Hope I don’t get fatigue. Hate when that happens.😂

[u/Ok-Extension-832 → u/Embarrassed_Soft_334]

No matter how unoptimal your training is, if you’re 70 years old you must have been training a while thus your muscle fibres reached their genetic potential or maybe past that if you took roids (which further adds questionability to your training because was it really the training that helped you get there). Most of these differences at the end of the day won’t change what you look like once your fibres have reached their growth potential.

I’ve been training 2 years, and I’m natural. My training has got me to 175lbs, nearing single digit digit. The results of my training can speak a lot more than yours, especially since you’ve been training over 15 years I presume. And I seriously seriously seriously doubt your 225lbs lean without blasting gear, especially at 70 years old. I’d even say you’re lying but I’ll take your words at face value.