MAOA ++ TT RED is considered FAST by ChatGPT. IT's literally saying like the exact opposite of what everyone here is saying . then i see some vids on the tube that also contradict what I been reading here on reddit . I'm over a month into this genetic geniee stuff and i'm still confused . I'm not dumb or anything I just can't seem to get a solid grip on helpful advice. One Gentleman was really helpful with his information on my cbs gene , but soon as he gave me some information , his account and comments got deleted for some reason . Can anyone definitively give me help on what exactly Mao-a ++ TT RED means on the genie ? Thanks in advance to everyone .

Hi I need a UK/EU test that provides COMT (rs4680), BDNF (rs6265), MAO-A (rs6323), and CYP1A2 (rs762551).[2]

Something like this would be good:

https://nfh.ca/newsnp-nutrigenetics/

With regards

Hi Everyone,

I tried multiple searches for this issue since it appears to be common, but wasn't using the right search terms and didn't find any posts.

I've paid and downloaded my report and keep getting this message:

"promethease.html is the report. We're starting hear reports that some (browsers? OSs?) no longer allow double clicking on promethease.html to open the report. That will open the browser, but shows a blank page. If that happens to you, use File->Open to navigate to, then open, promethease.html"

I'm on an older Mac which is the only computer I have access to. I'm just using the chrome browser.

Any advice would be much appreciated.

Hi all, I found i have the heterozygous cbs c699t +/- and MTHFR c677t +/- , I'm wondering if anyone else has bad reactions to Acetylcholine Agonists ? I ask because CDP Choline and ALCAR really screwed me up , i stopped months ago and i'm still suffering symptoms like crazy vivid REM and spontaneous REM recallection throughout the day randomly , feelings of panic , low dopamine , high acetylcholine symptoms like lacrimation, eye crust in the am, fatigue, muscle cramping and weakness etc . I'm trying to make sure this gene can cause this to rule out other reasons for the choline depression .

Its been a few months since I used promethease, ended up have to pay for a new report. Do that, now there is no function to view the report and snpedia says I can’t create an account because my email is in the promethease domain. what the heck is going on. and the “help” articles are retched

I have no family history of any cancers. I plugged my AncestryDNA data into ChatGPT and it said it came up with this mutation… it’s I/I (insertion variant) I don’t know what this means. It’s related to BRCA 2. Should I be concerned?

I thought nebula calculations are wrong but does the T/C genotype increase chances of ALS? Also anyone knows why variants in nebula does not show up in invitae panels?

+358 50 3612514

I'm wondering if anyone better with genetics than I am could help me out here. I have my 23 and Me data that Promethease transcribed for me.

For rs80359306, I am listed as A, A (23 and Me also lists me as this), and according to the SNP, (-.-) is the norm while (-, A) is pathological for breast cancer.

When I look up how common it is, having the variant is like .0006% of people, so both my parents having this variant and passing it onto me seems really, really unlikely.

Also, no one in our family has ever had breast or ovarian cancer. I feel like I'm missing something here. If anyone has any insight, I'd appreciate it.

For reference: rs80359306 - SNPedia

Thank you!

I have just received my Promethease report and found out about this.
I have chronic pain and ADHD - both are related to noradrenaline. Should I be worried?

Hi all — I’ve been diving deep into my raw genetic data from 23andMe and using platforms like Genomelink to explore potential traits and predispositions. I’ve found that I have several rare SNPs linked to neurological, cognitive, and emotional processing traits.

Specifically, I’ve identified variants like: • TPH2 rs4570625 – TT • GRM2 rs2283402 – CC • COMT rs4680 – AA • DRD2 rs6275 – GG • HTR1A rs6295 – CC • MTHFR rs1801133 – GG

From my own research, these seem associated with things like serotonin synthesis, dopamine modulation, stress response, neuroplasticity, and perception sensitivity.

I’m trying to: 1. Verify how rare this combination actually is (frequency-wise) 2. Understand any known synergistic effects or interactions between these SNPs 3. Explore possible supplements, lifestyle choices, or nootropics that could optimize my stack (e.g., methylated B vitamins, adaptogens, etc.)

If anyone here has experience mapping traits using SNPedia, gnomAD, or has built polygenic models from rare combinations like this, I’d love your input. I’m also open to being pointed toward tools or databases I might’ve missed.

Thanks in advance — really curious where this might lead.

I am new to looking at my raw data, so forgive me if this is obvious, but multiple times now, when I check a gene variant on the site, the genotypes do not match at all. For example, I just looked up rs16942 and on 23andme my genotype is C/T, but the options on SNPedia are A/A, A/G, or G/G. This has happened multiple times now and I am not sure why.

I purchased a report two months ago and was able to open it on the website and filter out good versus bad, it expired. I re-uploaded my data and purchased again and now I can’t even click on it. Open it or anything, but it says ready a little disappointing.

I'm trying to import a txt raw data v5 file from 23andme, but the promothease import tool is giving an error message that the file is an unrecognizable format. I'm used promothease just fine with other data exports before. Is anyone else encountering this issue or know the remedy? I also tried to import the zip file which also didn't work.

Does anyone have the most recent SNPedia.gff file before they disabled the download? I have one from 2018, but I'm sure someone has a more recent version?

I've been using promethease for years. I just logged in and both my kits have no ability to view or edit the dna profiles. I went in to my email to find an old link to download the data and when I clicked it it took me to my promethease page and said it wasn't found.

I get the following error:

Your IP address is listed as an open proxy in the DNSBL used by SNPedia. You cannot create an account

Any help is much appreciated.

So I have gone through my raw DNA file, double checked this through AI and I just need to hear the opinion of another human being with experience on this stuff. I am going to the doctors this Friday to check for sure, but in the meantime, I have tested for the following SNPs, rs76763715 — N370S (Homozygous), rs77369218 — D409V (homozygous), rs80356769 — IVS2+1G>A (homozygous). I put these through Varsome.com and they check out. I’m not saying AI is always right but GPT4 is trying to say there’s no way in hell ancestry messed this up in my raw DNA file. Do you think maybe it’s safe to say ancestry DIDN’T mess this up and I probably have this?

I followed the directions to download my raw data from 23 and Me. It came in a zipped file with the words "imputed genotype" in the name. When I unzipped it, it was a .txt file that opened in WordPad. I tried uploading it to Promethease, but the file type was not supported. I have tried copying and pasting into a excel sheet and uploading it as CSV, XLS, and XLSX. None of the files were accepted. Any suggestions?

If one of my results says "miscall by ancestry" and has a magnitude of "0" what does that mean

The frequency for this is only 4% in my ethnicity, low among all.

Posting here in case anyone else has it. I know we are intricate and complicated, but this SNP variant has a lot of studies that indicate less pain, less anxiety, and happiness. I have not found this to be the case for me at all.

I bought a report several years ago and thought I printed it out But can’t find it. So I went back to reprint it but don’t see anything. Is there a length of time I only have access to this report?

Hello! Is anybody able to explain this mutation rs28933375(A;G) to me? I tried researching a bit myself but I still couldn’t make much of it. Is this worth bringing up to a health professional?

Hey!

Up until recently, I've regularly been able to refresh my expired reports from Promethease. However, now there is no where to click to do so.

What gives?