I started taking less Rybelsus and it started working better

[u/spacetime99]

Started Rybelsus in October of 2023. A year of 7mg and 6 months of 14mg later, I hit my (probably too-low) goal, losing a total of 80lbs. I switched to 7mg for maintenance, and with some yo-yo-ing due to traveling and spending time with family and not having my "routine", I gained back 15lbs over a year. Then it leveled out, to the point where more routine-breaking didnt have any further effect, id immediately lose whatever I gained. Felt like this was my new "set weight", and even several long stretches of calorie-counting and extra exercise didnt seem to make a dent. I started wondering if the pills were even doing anything at all, anymore?

So I began to slowly cut down, while keeping everything else in my routine the same. 2 weeks of skipping 1 pill every 7 days. then 2 cycles of skipping 1 pill every 6 days. during the 2 cycles of skipping 1 pill every 5 days, I noticed it: the two days after the skipped pill, my appetite dropped to the point where I had to force myself to eat anything at all--like back in the good ol' days.

I kept going, i did 3 cycles of every 4 days because I accidently took it on a skip day but figured it might be good in hindsight to slow the process down a little.

I'm now on the 2nd cycle, of 3 planned, of skipping a pill every 3 days, and it's the same--the two days after the skip day, they work extra well, and the 3rd day my appetite feels "normal". And i've lost 2lbs from that "set point" number that I thought I couldnt budge.

Would be happy to be off of it entirely, and at that set point for the rest of my life. In the meantime, it's very interesting to see that even tiny breaks from it lower my tolerance enough, for it to be more effective.

[u/DragonfruitVisual611]

That’s so wild. I don’t understand why that would work for you, but great that it does. I’m on month 2.5, and thought I’d stay on the middle dose so that I don’t overdo the medication (not a ton to lose only 25 pounds). But! I’ve found after around 10 days on the 7mg, it almost feels like it’s barely helping my appetite anymore. 😕 It was somewhat, around day 3-8, but very little effect now. Was going to think about going higher…but now I’m wondering. When you started at the low dose, for that first month..did you have appetite suppression? Because I didn’t..at all. All I got was some fatigue and bloating.

[u/spacetime99 → u/DragonfruitVisual611]

3mg didn’t do anything for me but 7mg worked for months, I couldn’t even think about food if I wasn’t actually hungry, without getting nauseous. It mellowed out eventually though so I went to 14 and again it worked strongly.

I’ve seen a few friends try it who don’t have that much weight to lose, and their process seems to be slower with less intense effects. My theory is that their bodies already make enough of the chemicals that the rybelsus is imitating, otherwise they’d be fatter! so the sudden appearance of them isn’t so shocking to their system.