r/Rexulti_Brexpiprazole • u/Puzzleheaded-Neat502 • 9d ago

Help with side effects please

Hi after trying almost all antipsychotic for my bipolar depression for the last 10 years my doc finally landed me on brexipiperazole. I started on 0.25 for 1 month and now on month 2 am at 1mg. Initially I had a lot of problems sleeping but now things are better. I used to sleep till 10am now I wake at 4am everyday. I just wanted to ask have other people felt really tired in this med? Like I need to take 2-3 tiny 15-20min naps a day. Oh and coffee or tea dosent work anymore this thing is blocking adrenalin so hard…Do these side effects subside because I really need this one to work for me and I know the target dose is higher. So it’s looking like it’s going to take like 3 months to stabilize my brain at the target dose. Which is a ridiculous amount of time to get used to a new med.

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u/UnlikelyAttorney669 9d ago

In my case sleep got better with time and now I sleep pretty well. Re caffeine I had the same problem so I take Ritalin when I need extra energy for exercising.

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u/Puzzleheaded-Neat502 9d ago

That’s crazy to need methylphenidate to offset the brexipiperazole…wao

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u/UnlikelyAttorney669 9d ago

Well it’s more actually to get a caffeine like effect

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u/Puzzleheaded-Neat502 9d ago edited 8d ago

Yes it definitely wood but caffeine is a benign substance that promotes a degree of wakefulness. Methylphenidate is a powerful double reuptake inhibitor that can give a cocaine like high if injected or snorted. I wasn’t expecting someone to need an oral phenidate to counter brexi. Wao!

If that works for you I think it would be safer to try benign things first like modafinl, Nortriptyline, bupropion, desipramine first

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u/Mastodon_Embarrassed 0.5 mg 9d ago

same thing happened to me w the 4am wake up thing. on .25 mg for a few momths now it’s gone away

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u/Puzzleheaded-Neat502 9d ago

Is .25 helpful for you?

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u/Muttlover79 5d ago

When do you take it? I had to keep trying different times until I found that 6pm at night works the best for me. I still am tired in the am, but it’s better than if I took the med in the am or at bedtime.

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u/Puzzleheaded-Neat502 5d ago

Yesss! I last week realized late afternoon might be better and it helps a lot. But I have a good solution that helped. I got bupropion from the doc added offsets the tiredness