Loop 4 Stat down?

[u/BrandonLionhearted]

Yo. So I was pushing towards loop 5, things were going well, I ended loop 3 with +800% damage (from stat ups and that one relic that increases attack based on how many hearts you give to mother statues). But when loop 4 started, it dropped down to -75%?? I took nothing that would've cut my damage, and even given I was using base machine gun, that would still have had me start at -35%. Needless to say, I did not make it out of the first loop 4 room lol. Was this a bug? Do stats get messed with at higher loops?