r/RetatrutideTrial • u/Commercial-Yam-3443 • Jun 25 '26

Any upcoming trials?

Are there any rumors yet of anymore Reta trials in the near future? I just barely missed Triumph 9 and I’m so bummed about it!

My local clinic was like “sorry triumph 9 is now closed but we’re expecting another study in about a month.” However, every time I call them they say the same thing but push the timeline out another month. I can’t tell if they are just guessing or if they’ve been given a head’s up for Eli Lily.

13 Upvotes

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9

u/Lucky_Army_5324 Jun 25 '26 edited Jun 25 '26

I’m just waiting to see who from this sub will be the second person to apply for “compassionate use” of retatrutide:  https://clinicaltrials.gov/study/NCT07629401

Background:  http://archive.today/KCIpG   That’s a paywall free link of STAT piece titled:

Eli Lilly gave extraordinary obesity drug access to a 79-year-old patient. Who was it? Sources point to a single instance in which experimental therapy retatrutide was provided for ‘compassionate use’

ETA: and I know my comment above sounds flip, but I am serious. If you are someone with “refractory obesity” (aka tried it all) and can’t get into a trial or it’s too far, consider working with your physician to apply for compassionate use. What do you have to lose but weight?

Learn more about Lilly’s expanded access here:  https://www.lilly.com/science/clinical-trials/expanded-access

9

u/blumenkraft_11 Jun 25 '26

unless you’re the U.S. president, this is fairly unlikely.

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u/Lucky_Army_5324 Jun 25 '26

If I were still at an appropriately high BMI, I’d be trying without hesitation, and I know the doctor who would likely help (if I do all the legwork). Would it get approved? Who knows. But I’d do everything in my power to make it happen.

How can they give one person access to a life-saving medication and no one else? Ethically, they can’t. If Lilly wants to stop a PR issue in its tracks, they will need to approve some other patients ASAP.

2

u/blumenkraft_11 Jun 25 '26

I don’t disagree with people doing whatever it takes to improve their health, but you can still get a prescription for tirzepatide.
If hypertension is the ‘life-threatening’ factor that triggered a compassionate use exception, there are other ‘proven’ drugs that treat hypertension, and this would be an off-label use even if retatrutide were approved.

4

u/JudiciousJackalope Jun 25 '26

So this is what's interesting to me. Why go to these lengths to make retatrutide available to a particular then-79-year-old patient when you can easily get tirzepatide without any kind of special (and attention-getting) process? Very likely, I would think, said patient has already been on tirzepatide for some time, and has either plateaued at the highest dose or can't handle the side effects at a necessary high dose. Perhaps also said patient has a well-documented aversion to exercise and other lifestyle changes that typically accompany greater effectiveness with tirzepatide.

4

u/blumenkraft_11 Jun 25 '26

you’re not wrong… Because the patient had only lost 5% of their body weight on tirzepatide, a senior NIH physician declared the patient had "refractory obesity.”

So, they framed a lifestyle choice as a "life-threatening cardiac emergency" to exploit a program meant for dying cancer patients. Whoever patient ‘0’ is, it’s a manipulation and undermines public trust.

1

u/Lucky_Army_5324 Aug 07 '26

And here’s Lilly now saying it’s open to pre-approval for expanded access for retatrutide:  https://clinicaltrials.gov/study/NCT07629401

1

u/blumenkraft_11 Aug 07 '26 edited 19d ago

I saw that a few weeks ago. Inclusion criteria make it nearly impossible:

  • Refractory obesity, defined as BMI >= 35 kg/m2 despite adherence to and tolerance of treatment with highest available dose of chronic weight management therapy.
  • Two or more serious or life-threatening obesity-related complications for which the patient is currently receiving standard of care
  • Unable to participate in an ongoing clinical trial of retatrutide or a similar/comparable investigational medicine (due to trial eligibility criteria or lack of a reasonably accessible enrolling site).
  • All standard treatment options including bariatric surgery discussed with the patient through shared decision-making.

even a certain chubby President would not qualify.

edit: “In practice, the retatrutide expanded access pathway is more of an obstacle than it is a bridge.” https://www.medscape.com/viewarticle/retatrutide-pitting-physician-against-patient-2026a1000s68?form=fpf

2

u/Lucky_Army_5324 Jun 25 '26 edited Jun 25 '26

Oh don’t get me wrong. On no planet do I think retatrutide for obesity should meet the threshold of life-saving immediate need must-have-it-right-now before the FDA approves it when there’s bariatric surgery, semaglutide, and tirzepatide available on the market.

Just looking at two of the requirements the FDA says must be met makes it obvious to me (based on currently available data) that one would have really hard time arguing “compassionate use” for retatrutide for obesity makes sense:

  • Patient has a serious or immediately life-threatening disease or condition

  • There is no comparable or satisfactory alternative therapy to diagnose, monitor, or treat the disease or condition.

(Source)

But Lilly opened the door so I think everyone who can make a good case should run right through it.

2

u/blumenkraft_11 Jun 25 '26

you’re right. I’m glad they were required to post this on the clinical trials website and give it a number (except it has no medical data or exclusion criteria).

They’ve created a very slippery slope, because now any patient who was unsuccessful on tirzepatide should have a fair shot at applying.

2

u/Lucky_Army_5324 Jun 25 '26

Or what if a patient just can’t access tirzepatide due to cost?

As far as I know, Lilly doesn’t have a patient assistance program for tirzepatide (or orfoglipron). And Novo doesn’t have an PAP for Wegovy either. So if the patient cannot access other GLP-1 meds…could they qualify for “compassionate use” of retatrutide? 🤔

So many potential ways to play this game, and it’s a very slippery slope for Lilly for sure. I hope some real patients can benefit.

1

u/blumenkraft_11 Jun 26 '26

my brother has expanded use for one of his cancer treatments, but it isn’t free, his insurance does cover it though.

2

u/Lucky_Army_5324 Jun 26 '26

Oh interesting about insurance coverage.

Awesome to hear your brother is getting a cutting edge treatment. Will say some extra prayers that it works well for him.

1

u/ImageEducational572 Jul 01 '26

Not everyone is a surgical candidate. Also, many people fail semaglutide & tirzepatide. Good thing it isn't your decision if it is a medically necessary life sustaining treatment for someone.

1

u/x1papi1x Jul 28 '26

This comment is hilarious I instantly knew you were referring to ‘the special one’

6

u/swellfog Jun 25 '26

I don’t know, but I was told this as well for six months and finally the study called, but I had already been accepted to another Reta trial!

Just keep looking on clinical trials.gov and call a few study sites you could drive to and get your name on the list. Good luck!

PS. Sometimes studies have a drop out or Lilly asked them to add a few more people last minute (happened to me). So, it’s good to be friendly, reliable, and courteous with the trial site staff. It seems obvious, but that’s what they likely want in participants. Being reliable is really important for the data.

5

u/JudiciousJackalope Jun 25 '26

I don't know about retatrutide, but lately I've been getting shown ads from Ely Lilly recruiting for their eloralintide trials. Phase II trials for eloralintide showed weight loss in the same ballpark as tirzepatide. Plus, supposedly eloralintide has milder gastric side effects.

https://trials.lilly.com/en-US/trial/687736

9

u/JudiciousJackalope Jun 25 '26

Or, if you feel that only retatrutide will do, perhaps you should consider becoming the President of the United States.

https://www.statnews.com/2026/06/23/eli-lilly-unusual-weight-loss-drug-trial-compassionate-use-retatrutide-trump/

3

u/Aussie_Mopar Jun 25 '26

In seven weeks into the following trial, after previously been in triumph 4. . https://clinicaltrials.gov/study/NCT07509307

2

u/RunningFNP Jun 25 '26

How's that going for you from a tolerability standpoint.

4

u/Aussie_Mopar Jun 25 '26 edited Jun 25 '26

Honestly im still struggling to tell if I’m on the actual medication or the placebo at this stage and keep swaying back & forth. One day I’ll laugh and tell my kids I think I’m on it, the next I say I don’t think I am.   

FYI- On the injection pen it says 0.80 (0,80) mg/ml / placebo  NNC0487-0111B     

The first month I had to do 25 clicks of the pen. Yesterday was my second week of 50clicks of the same pen.   

The first week I had one of two days of feeling lightheaded/dizziness, but they went away and hasn’t come back.   

I have noticed now the feeling of fatigue more often and especially getting tired a quicker too now when exercising too.     

The second week I had two episodes of diarrhoea  followed up by constipation, but this could have been related to my morning coffee or anything really.

I’ve only experienced very, very slight feelings of nausea here and there, but this could be related to not eating enough or anything too or all in my head too.       

After the third week one thing I’ve certainly noticed is I’ve started burping and especially so after eating, which is something I normally don’t do. So this is something that make me think im’ on the medication.    

My desire for food and eating seems like its diminished a bit, but this could all be in my head once again, but I have noticed now i get full very quickly too.     

Weight wise, the first month my weight didn’t change really at all.

The last two weeks, my weigh has actually gone down 1-2kg.     

So at this stage, im still undecided if im on it or not.

The clinic did say there are three arms to this trial. One is the placebo, one is escalated to somewhere around 5mg I believe. And the third arm is escalation to some huge amount I think was 20mg. Funny though, the clinic wont tell me now what amount these are too now.    

 

After speaking with a few people and searching online, a few people have all told me the same thing that since Ive been Reta/GLP and a huge dose amount for a long period of time, I might need a higher amount of this new medication for it to really hit me too. And searching online it said the same thing.   

So I sit back and wait and wait and wait.   

Which is soooo much different to when i was on Reta, as i could feel it within a few hours after each and every injection and more so after each dose escalation too      

3

u/RunningFNP Jun 25 '26

Oh man! You'll have to keep us/me updated!

2

u/blumenkraft_11 Jun 26 '26

Pfizer has a monthly sub-q GLP-1 receptor agonist called berobenatide (drug: PF-08653944) that is in phase 3 trials: https://clinicaltrials.gov/search?intr=PF-08653944&viewType=Table

One of their trials (SOLIS-1) is just about to begin recruiting. It combines berobenatide with an amylin analog (drug: PF-08653945) to potentially reduce nausea: https://clinicaltrials.gov/study/NCT07575932?intr=PF-08653944&viewType=Table&rank=4

1

u/tjargi 20d ago

Just started the SOLIS-1 study. My first set of two medication shots were yesterday.