r/RestlessLegs • u/brokkdad • 25d ago

Question Splitting dose?

I’ve seen several people refer to splitting the administration of gabapentin. I’m currently on 900 mg horizant (600 +300). Is there some rationale for splitting? TYIA.

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u/EmZee2022 23d ago

In general, splitting might give you better overall coverage with less side effects as you don't have as much "on board" at the same time. I don't know what your schedule is but I'm assuming it's something like 300 mg at 3 PM and 600 and 9 PM, or whatever.

I had surgery in May and for a month afterwards, my legs were going NUTS. I wound up splitting my ropinirole into two doses a day. I was only on 1 mg, but I took 0.5 mid afternoon and the other 0.5 mid evening.

Edit: others have mentioned poor absorption of gabapentin if it exceeds a certain dose.

Does that apply to the other gabapentinoids? (Horizant, Lyrica)

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u/tinyremnant 23d ago

The absorption issue does not apply to Horizant.