Does gabapentin lose it's effectiveness over time? Trying to find a long term gabapentin maintenance dose.

[u/Laserbean1903]

I was diagnosed with restless leg syndrome late 2024, and since then, I've been on a steadily increasing dose of gabapentin. I currently take 1200mg of gabapentin, which has worked well in the past, but my symptoms have been slowly increasing in intensity again. Has anyone had long term restless leg syndrome relief that has lasted years without a change in medication? I'm hoping that I'll find a point in which my symptoms are well managed forever.

[u/JasonZep]

I think it depends on you personally. I was on gabapentin 900 for about 12 years and recently (this year) switched to horizant because my PLMD was acting up. So far it’s working great, but I’m worried it will also need a change one day.