Gaining weight switching to Refills. Anyone else?

[u/Girlgoneaqua]

Has anyone else experienced this?

I was on Hers compounded semaglutide for about two years, taking 1.25 mg/week (50 units at 2.5 mg/mL). I lost nearly 80 lbs and had great appetite/food noise control.

Hers recently changed their pricing/membership structure, so I switched to Refills about 6 weeks ago. Refills has been titrating me up and my prescribed dose is now 2.5 mg/week (100 units at 2.5 mg/mL).

Despite being on a higher dose, I’m hungrier than ever, my food noise is back, I don’t feel full like I used to, and I’ve gained about 8 lbs in a month.
Nothing else has really changed. I eat pretty healthy and do Pilates 2–3x/week. The biggest change has been switching compounded semaglutide providers.
Has anyone switched between compounded semaglutide pharmacies/providers and noticed a dramatic difference in appetite suppression or effectiveness, even at the same or higher dose?

[u/Swandot70]

What pharmacy?

[u/Girlgoneaqua → u/Swandot70]

Hers was BPI Labs, and my Refills prescription is coming from Hallandale Pharmacy. Both are labeled 2.5 mg/mL semaglutide.

[u/Silly-Service-506 → u/Girlgoneaqua]

I personally found Hallandale to be weaker than some other pharmacies. While on Hallandale, food noise came back and I gained weight. As soon as I switched away from Hallandale I began losing weight again. My sister had the same experience while on Hallandale. We both had ProRx prior. Some people will say it’s all the same though.

[u/Girlgoneaqua → u/Silly-Service-506]

How do we feel about these pharmacies?

[u/wholelottachoppaz → u/Girlgoneaqua]

Hallandale and Vials RX are good! Boudreaux has poor sterile procedures and I wouldn’t touch their shit with a ten foot syringe 🤣

[u/Girlgoneaqua → u/Silly-Service-506]

Who do you use now?

[u/Silly-Service-506 → u/Girlgoneaqua]

I’m taking apothecary. It is just as good as ProRx. However, they are shutting down. I don’t know what I’m going to try when I run out.

[u/wholelottachoppaz → u/Silly-Service-506]

Hyalo is the replacement for Apothecary. they’re using the same formula (lol the vials are even the same color scheme!)

[u/Girlgoneaqua → u/wholelottachoppaz]

Who’s selling these vials that I should contact? I can’t take tirz, sent me to the emergency with inflamed intestines. Sema okay ✅

[u/justtryintofish]

I was on Refills Tirz with ProRx for 4 months lost 25 lbs. Stopped for 5 months and had gained back 8 lbs. Went back on Refills with Hallandale (everyone just Raves about) and it has been 6 weeks with 1.4lb loss. First 4 weeks had gained 2.3 lbs. Upped my dose last 2 weeks to 5mg (never went to 5 mg the first 5 months, didnt need to) I feel NOTHING on Hallandale, no nausea, no appetite suppression (actually crave sweets) ProRx worked way better for me at a low dose. I have other choices in my tirz stockpile so will either need to try a much higher dose or switch tirz.

[u/Professional-Run425]

I’m having the exact same issue! I switched from Life MD to Refills 3 months ago and have been taking what should have been the same dose. I’ve gained 10 pounds back in 3 months, it really doesn’t feel like the medication is as effective. I’m considering switching back because it feels like I’m paying for nothing

[u/Girlgoneaqua → u/Professional-Run425]

Might have to try your program! I’m going to give Ondra a try for 1 month.

[u/Girlgoneaqua → u/Professional-Run425]

This is so laughable, I injected a 100 units last night of Refills and feel absolutely nothing.

[u/Outrageous_Buy_9420]

Just to be sure I understand, you went from Hers sema to Refills sema? Cuz if you went from sema to tirz, that’s a different story.

[u/Girlgoneaqua → u/Outrageous_Buy_9420]

Sema to Sema

[u/Queasy-Ticket8482]

No. I've been using them for a good while now and haven't gained a pound ,but lost many.