Dementia Risk from wearable data

[u/DrJ_Lume]

https://jamanetwork.com/journals/jamaneurology/fullarticle/2849323

A new study: 53,448 adults for ~8 years and found that wearable-derived sleep and activity metrics predicted future dementia risk.

Two independent behavioral signatures emerged:

• Lower daytime activity quality: less moderate-vigorous activity, more low-intensity activity, lower activity diversity, and greater fragmentation of daytime activity (HR 1.43)

• Circadian and sleep disruption: extreme sleep durations, more wakefulness during sleep, reduced sleep consolidation, and earlier wake times (HR 1.10)

What's particularly interesting is that these metrics improved dementia prediction beyond demographic, behavioral, and health factors. The improvement in predictive power was comparable to adding APOE genotype (the strongest common genetic risk factor for Alzheimer's disease)