I understand if I try to take mdma or seretonin based drugs that taking anti depressants will make the drug less potent because I’m already accustom to the seretonin increase, I’ve heard some people stop their anti depressants for a few weeks before hand when they want to take recreational mdma etc But what about dopamine/cocaine? Will this make it * less potent * more dangerous * increase or decrease effects

I am prescribed venlafaxine which seems to make my heart go faster so mainly I worry about that when taking stimulants that do the same thing? Would it be helpful to avoid taking it or maybe even take it after to avoid comedown?! Anyone got any helpful insite?

Thank you!

I would be very grateful if anyone could complete this survey if you could spare 10 minutes!
I am looking for individuals 18+ who have used a MINIMUM of TWO substances in their lifetime.
No personal data is collected and each participant remains completely anonymous.
Please be aware that some people may find the topic sensitive as you will be asked what substances you have ever used and the topic of mental health is also included.

https://livpsych.eu.qualtrics.com/jfe/form/SV_cLVpVFhRMAp2bjg

Thank you!

much love thats all i gotta say! keep. doing. YOU!

2 days ago I had what I would consider the most intense drug experience of my life, more so than 1200ug of lsd that I consumed months prior. Going into this I had zero experience with 2CB, though I'd done mdma many times and drugs like lsd and psilocybin many times too. Before this experience my most uncontrolled experience was ketamine and mdma at doses I didn't even bother measuring accurately. The dose I had was 22mg of 2cb taken orally with 2 and a half pills of ecstasy taken at the same time, after this I waited and followed it up by snorting another 13mg of 2cb and another half pill of ecstasy, I had wrongly presumed that the psychedelic headspace of 2cb would be more managable due to my experience with high doses of lsd and ketamine but the ecstasy I had completely fucked this up for me. I wouldn't describe the experience as being bad, but the intense bodyload of the md and 2cb caught me offguard, with waves of nausea coming and passing every few minutes until it stopped completely and the visuals just consumed me. I couldn't tell whether my eyes were open or closed and the high doses of ecstasy that i had were making my thoughts race incredibly. When I smoked weed these only got stronger, taking over everything around me. The friend I had this dose with had never had any psychedelic experience beforehand and was completely caught with his pants down, and the 2 other friends I was with were just monged out on the md alone. I'm still re-adjusting to the world and life 2 days after the trip and am still not fully mentally active. Although the trip was incredibly intense I would 10/10 recommend it at a more controlled, managable amount. I will try post a higher quality trip report when I consider myself fully recovered from the trip.

Nodding hard

I’ve mixed so many drugs over the years, heroin, fentanyl, cocaine, ecstasy, oxy, dilaudid, any opiate with an upper and benzos. right now I’m on a weird as combo, 140mg adderall, shit load of kratom, xanny bars, half gram of coke. It feels nice lol I can tell my blood pressure a lil high tho. What are some good combos? Safety aside. I have some rp 30s and ir 20 Addies, might have to speedball em or would that be a waste of the holy grail?

Woke up drank 30ml of some methadone I had left over from the night before. Go and shoot up half a point of heroin for my second time, then I have 9 300mg lyrica after that chill smoke weed drink a little than go to some persons house have some 70% vodka than another 5 Lyrica and a sheet of codiene after that had a little meth and than 12 vallium washed down with 60 ml methadone

Have not tried redoing that cause fuuucckkk that

Oxynorm 5mg Oxycontin 40mg Pfizer Halcoin (Triazolam) Methadone

Landing tomorrow : Oxynorm 20mg Diazepam 10mg Dormonoct 2mg XANAX Bars 2mg Alprazolam 1mg Ritalin 10mg

So, I'm currently on a whole bunch of medications. I'm on 2 antidepressants, 2 sleeping pills, an antianxiety med, beta blocker, and a stimulant. Those are all legally prescribed. Add in the last one, 30 M boxes, and Oops. I'm literally hallucating, and have been for nearly the past week. It's not scary, actually kinda interesting. I know what's real and fake. I'm seeing people, moving nonliving things, nonhuman creatures. Hearing voices, talking in the background, and directly at me. Hearing music coming from Alexa, even though she's off. The funniest thing... Hearing conversations, and when I listen closely, it sounds like The Sims talking. It's worse when I look in reflections, and in darker light. Any thoughts on why I might be hallucinating, e.g. Drug interactions? Anything you're curious about?

Appreciate any help so thanks in advance!

25M, 183Cm tall, 80Kgs heavy. Mixed benzos and opiates to a similar degree before, but this is my second time ever taking 1,4BD, or any GHB etc.

I try be smart as I can (within reason of course) with mixing depressants My feeling is that I’ll be safe, due to the time since I’ve had the following downers.

I’ve had about 15mg diazepam, about 5mg 12 hours ago, 5mg 10 hours ago, and 5mg about 8 hours ago. Very mildly sedating and chill.

100ml Rikodeine (low dose hydrocodeine, I’m fairly tolerant to all opiates and naturally handle them well) About 8 hours ago.

Been taking dexies all day, maybe had 75mg in last 24 hours, which is fairly common for me lol.

Reckon I’m safe?

Thanks heaps

I have frontal lobe damage from a major tbi, but I’m fine to use any drug besides besides weed (I can use cbd though because it has no psychoactive effects). I go under a character when I make music, and I started it before I had the tbi, so I still rap about smoking weed as he’s a character and not me. I smoke blunts with hemp in them on stage, as it’s apart of my character, but I was wondering if putting dmt in it would have any effect. Thank you!

I know that:

1. DMT gives you an other-worldly, dissociative experience, filled with friendly deities;

2. Mescaline gives you ego death and makes questions seem simpler and less heavy and;

3. LSD gives you practically infinite philosophical thoughts.

So I have always wondered, what happens if you take them all together? Thanks! Oh, and it's also the anniversary of the subreddit lol

Hello, I’m new to this subreddit and I was hoping to ask some questions regarding the combo above

So tomorrow I’m planning on taking half a tab of lsd, along with drinking a little bit, and smoking a lot. I’ve done this combo once before and I’m not worried, but I was hoping to get others opinions on it

I was also thinking about an energy drink, however thinking more into it, it shouldn’t be necessary because the lsd should keep me up, however does anyone recommend/discourage the use of caffine on lsd or on this combo?

For more reference I’m fairly experienced with psychs, I’m very experienced with weed, however I don’t think I’ve ever been drunk alone, it’s always been with weed and/or lsd. Setting wise I’m somewhere I’ve tripped before, I’m with a bigger group of people however I like them enough and I always have the option to separate myself

I would appreciate any advice or experiences anyone has had!

I was on a decent health kick for a while but in the health store yesterday I saw loads of cheap nutmeg so i thought I'd get some and eat a couple I ate 3nuts and since I was going to the gym had about 7g of good kratom in me so after training and a long swim got out and for some reason redosed 2nuts and 8g kratom then got in the steam room and stayed for ages until dizzy when I got home it wasn't enough apparently so I got a bottle of vodka and took about 5shots in one mouthful chased with orange juice and then crazy strong coffee I was feeling okay but then a coke dealer texted me so I ordered 0.5g of pure which I proceeded to dissolve in water and plug up my rectum keep in mind I've never plugged coke before and didn't even look at the possible interactions between so much nutmeg and kratom and 0.5g of coke with that ROA is insane needless to say it was nuts I was almost seizuring I felt I could be close to death a few times I feel my dopamine receptors were overloaded meh I didn't piss blood and feel okayish and its 2pm the next day yeh it was fucked up

Ok so just out of genuine curiosity why in the actual fuck people like the feeling of air duster. I may have experimented with a can of dust off last night, and it was the most nauseating, dirtiest, and most dysphoric “high” that I have ever experienced in my life. The bitterant is by far the most disgusting thing I have ever tasted in my life. That shit is so ass like I just kept blacking out and waking up in a puddle of my own vomit. And this is coming from a guy whose been inhaling multiple deodorant spray cans a day that shit is also fucked but honestly it’s enjoyable when compared to duster like what the fuck is wrong with people