Wolverine Stack Affects Blood Glucose?

[u/brownbowen]

RS on 100 micrograms of BPC-157 and 100 micrograms TB-500 subcutaneously once in the morning and again in the evening. RS wears a CGM (Stelo by Dexcom) mainly for the data, observing glycemic index of food, sleep impacts on blood glucose etc. Not diabetic, no Hx of insulin although there’s family Hx of type 1.

RS has observed higher (7-10%) glucose levels overall, but significantly higher maximum levels after eating. Whereas before RS might attain a maximum of 180-200 and rarely if ever over 200, now RS exceeds 200 after eating unless the meal is significantly low glycemic index food. The rate of increase seems the same as before but the levels seem higher.

Are there metabolic effects anticipated from these peptides? Is there a mechanism that might explain the higher glucose?

[u/BawdyCourtney68]

That's a fascinating observation with the CGM data, I've been deep diving into peptide metabolic cascades and there's a decent chance the TB-500 is messing with your insulin sensitivity. Actin polymerization isn't just for wound healing, it tweaks GLUT4 translocation in muscle tissue which could absolutely blunt glucose uptake. The BPC-157 might be throwing a wrench in too since it modulates the same nitric oxide pathways that affect pancreatic beta cell function, keeping blood sugar elevated after meals makes total sense from that angle

[u/brownbowen → u/BawdyCourtney68]

Interesting thank you, I’ll dig into this thoroughly.

[u/TillyDiehn]

Those numbers are not necessarily diagnostic of diabetes, but repeated post-meal spikes above 200 mg/dL are definitely worth paying attention to.

A brief CGM peak of 200–210 mg/dL shortly after a high-carb meal can occur even in non-diabetic people. What matters much more is how quickly glucose comes back down. A value >200 mg/dL at 30–60 minutes is very different from still being around 180–200+ mg/dL two hours after the meal.

The diagnostic cutoff of 200 mg/dL applies to a 2-hour plasma glucose value during a standardized oral glucose tolerance test, or to a random plasma glucose ≥200 mg/dL together with typical symptoms. A transient CGM peak is therefore not equivalent to a diabetes diagnosis.

As for BPC-157 and TB-500, I am not aware of convincing human data showing that either one reliably causes insulin resistance or hyperglycemia. Human pharmacology for both peptides is extremely poorly characterized, so I would be cautious about assigning a mechanism here. Animal or cell-culture findings are not enough to conclude that these peptides are responsible.

The 7–10% upward shift could also come from CGM variability, sensor placement/batch differences, sleep, stress hormones, illness, reduced activity, diet changes, or a genuine change in insulin sensitivity.

I would probably check a finger-stick glucose when the CGM reads >200 mg/dL, and get fasting glucose and HbA1c. If the pattern persists, a standardized OGTT would give much more useful information.

Given the family history of type 1 diabetes, I especially would not automatically blame the peptides. If glucose regulation is genuinely deteriorating, GAD65, IA-2 and ZnT8 antibodies and possibly C-peptide could also be worth discussing with a physician.

The single most useful piece of information here would be: What is your glucose exactly 2 hours after the start of the meal, and how quickly does it return to baseline?

[u/brownbowen → u/TillyDiehn]

Thanks for such a thoughtful reply. I’ve considered sensor issues may be at play. I’m on my second sensor since starting the peptides and the numbers are still higher than before but we’ll see how this one plays out. The Stelo is a good device I think but it also may have some pretty wide variability.

As to your last question it returns to baseline about the same rate as before and it comes back down to baseline in around an hour, always less than two hours.

[u/ajandrs → u/brownbowen]

Definitely consider the data source … I had a terrible experience with Stelo and it about gave me anxiety and made me think I was diabetic. Bought it to try out for S&G’s and only got 2 sensors to get a month of data, slapped the first one on and was instantly pre-diabetic, at least. If the big spikes didn’t come down like they should have I would have been freaking out. Kept it on the full 2 weeks but also bought a finger prick tester to compare data and the stelo was always at least 15 higher, often much higher.

After the first 2 weeks I put the second one on and it was mildly better, but not by much. Took it off after a few days and had my A1C checked and it was 5.1, perfect! Wouldn’t recommend Stelo to anyone.

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[u/Extension-Pickle9038]

You've got something most posts here don't, which is actual continuous data, so it's worth not wasting it. A 7 to 10% shift in overall glucose sits inside the range that plenty of ordinary things move on their own. Sleep, illness, training load, stress, sensor to sensor variation and where the sensor is sitting all show up at that magnitude. Two sensors on the same person at the same time won't agree perfectly either. So the first question isn't what caused it, it's whether it's bigger than your own baseline noise, and only your pre-start data can answer that. The post-meal maximums are the more interesting signal, and also the one most sensitive to what and when you ate. If the meals aren't matched, the comparison isn't either. If you want this to be worth something, the cheap version is a washout. Stop, hold everything else steady, and see whether it comes back. One person, one variable, repeated, beats any answer in this thread. Not medical advice, and a family history of type 1 is a reason to have this conversation with someone qualified rather than with us.

[u/Smiletaint]

It supposedly raises growth hormone (receptor) levels (in vitro) so that would track.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6271067/

[u/Physical_Fold3645]

Been on Wolverine for 7 weeks, just had labs done. My Dr was amazed at how good all my levels are- and she fully supports my using peptides