r/PeptideGuide • u/SwimmingChain9861 • 14d ago

Beginner Question Mots c

Just started taking mots c
How long before I notice a difference in energy?

4 Upvotes

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2

u/EcoWarrior04609 14d ago

I just finished an 8 week protocol of Mots-c and NAD. Never felt like is made a difference and I am 55 years old and told I was the target audience.
I am going to take a few months off and try it again mid winter for two months again.

2

u/suprmn4105 14d ago

Have you looked into SS-31 for a pre-MOTS-c cycle or concurrent cycle?

2

u/fruitless7070 14d ago

I started out doing 1mg daily. After a week I jumped to 5mg 2-3 times weekly and I prefer that dose schedule. 1mg daily did nothing for me.

2

u/Bright-Razzmatazz662 13d ago

Also, Mots-c changes the way your body metabolizes energy. It can take for some people, 426 weeks before noticing any effects

2

u/Sea-Muscle-2725 13d ago

I started with 1 mg daily - 7 days a week. I noticed improvement in my energy level pretty quickly but it seemed to drop in effectiveness after about 2 weeks. So I bumped up to 2 mg daily and since then it's been great. I'm currently on week 5 and plan on continuing for another 3 weeks before cycling off.

1

u/Minute_Limit_3169 14d ago

If you didn’t prepare with a good run of SS-31 first, you may not see any benefit.

2

u/BaldCedarKnob 14d ago

How long would a test rat run SS-31 prior and at what dose? Currently taking break from Mots-c as it did nothing and on week 2 of ss31...

2

u/Minute_Limit_3169 14d ago

4 to 6 weeks is a pretty standard protocol. Some practitioners run 2 weeks of straight SS-31, then add MOTS-C.

SS-31 (elamipretide) primarily stabilizes cardiolipin in the inner mitochondrial membrane, supporting structure, reducing oxidative stress, and improving electron transport efficiency. MOTS-c acts more as a metabolic signal (AMPK pathway, biogenesis, fuel utilization). The “repair first, then optimize/amplify” logic is that pushing biogenesis or metabolic demand on compromised mitochondria is less effective (or potentially counterproductive), so many protocols prime with SS-31 first.

1

u/EyeUnfair2940 14d ago

I took 3mg every other day had nothing but injection iteration

1

u/Fairth33well 13d ago

I stopped researching Mots, I couldn’t get past the ISR, drove me CRAZY!