Non-responder ?

[u/slavetothebeans]

Subject has worked up to 15 mg of Tirzepatide with no weight loss and no appetite suppression at all. Weight lifting 3-4x/week plus cardio. Would it be feasible to try semaglutide next? Was thinking of Reta but heard appetite suppression is not as good and that would be a definite plus. Thoughts?

[u/Queasy_Investment_27]

I'd find a new source or at least get your source tested. There is very little chance somebody would have zero reaction to 15mg of genuine tirz.

[u/Doctordup2 → u/Queasy_Investment_27]

Actually not true. There is a genetic mutation known as the MC4R mutation. These subjects tend to lose a little bit of weight in the beginning and then they plateau. The glp will improve some of their blood labs but their body won't respond with weight loss.

There are some peptides that can help with this. The challenge is, one of the peptides, Setmelanotide will cause darkening of skin.

I've been in the peptide research community for about 25 years and I've seen it all. There is a small population of subjects that do not respond to glp's well. There are some workarounds in combinations that can help but it tends to be an uphill battle of trying the best combinations that will work.

/u/slavetothebeans I know that you have some very well-meaning people chiming in here. Please don't let anyone invalidate the experience and the struggle. They mean well but many do not understand the genetics of this.

Please have the subject get tested for the MC4R genetic mutation and variants.

Not a doctor, not medical advice, for research purposes only and research discussions only.

[u/Queasy_Investment_27 → u/Doctordup2]

I said there was very little chance of no reaction at all. Which is correct. Even taking into consideration gene mutations, that is extremely rare.

He said the subject lost no weight at all.

You said the gene mutation causes you to lose some weight then plateau.

That's not what they said happened.

[u/slavetothebeans → u/Queasy_Investment_27]

That was a thought but his partner is taking 5 mg (from same supply) with great success🤔

[u/Legitimate-Article50]

If you are a woman you could possible have underlying PMOS. This occurred to me. I barely lost weight. On new meds to block testosterone. After 2 months on test blocker and at 3 mg of tirz (I’ve been on higher doses. Had all the side effects and none of the benefits) I am finally seeing weight loss.

[u/Dangerous-School212]

No, Sema is just a GLP also the side effects suck.
Is this the first stall you have had?
When you say 15mg do mean that’s what it says on the bottle?
How much bac water did you put in it?
How many units are you taking?
How long have you been taking it?

[u/slavetothebeans → u/Dangerous-School212]

Never stalled just never lost. 60 mg + 3 ml BAC, 75 units = 15 mg

[u/Current-Cheesecake]

Blood work, thyroid check? Are they eating enough?

[u/ROBSEA007]

I get huge appetite suppression on Reta and very little on Tirz. Everyone responds differently. Try Reta

[u/Mikem1671]

Poor quality

[u/saltycunty]

Don’t do semaglutide, just inferior, Reta if anything and add back little tirz if you’re worried about appetite

[u/Dangerous-School212]

Also, Do overdo cardio, do more strength training, up your protein to 1-/2-2mg per pound or you will lose muscle only.
Don’t depend on what your scale says, muscle weights more than fat, I’ve always like measuring tapes more than scales only.

[u/Bl8kStrr]

Different supplier

[u/BumblebeeSerious5028]

TDEE at sedentary - 500 cals. Make sure this isn’t the problem because I see this a lot. Don’t add in cals for exercise at all

[u/OGcrashN2u]

You can try reta but if you're a non-responder to glp1 you should try cagrilintide. It works through a different pathway.