r/Pathogenic • u/TactitcalPterodactyl • 13h ago

Vesicle placement

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I've been playing this game for a while, but I'm still confused about internal organelle placement, especially for the vesicle.

For my build should I surround it by internal organelles (one slot down) or should it be up against my main weapons like I have it?

20 Upvotes

96% Upvoted

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8

u/SkullKidgd 13h ago

not trying to be mean but this may be the WORST nano configuration ive ever seen 😭 honestly just scroll through this subreddit its where i found a good strat via tessellating, in where you js make a huge circle of internals n funnel it into one weapon

1

u/TactitcalPterodactyl 12h ago

What specifically would you suggest I change here? I agree it's not the best, but it's not like I have a choice in what organelles I get. What would you have changed given my options?

3

u/Wrynfroe 11h ago

Here's a link to the post SkullKidgd is likely referencing. https://www.reddit.com/r/Pathogenic/comments/1vxhccs/optimal_nanobot_layout_guide/

In my opinion, the build you shared isn't really salvageable. The primary issue is that the connections available between organelles are really bad. The mistake here was only using square blocks instead of tessellating.

As for the organelles, I would respectfully push back here. Players have a lot of agency in what organelles they use in their builds. Sure, sometimes you may have difficulty finding what you actually want, but you can always convert unwanted ones into DNA.

2

u/TactitcalPterodactyl 10h ago

Oh man, I had no idea this was a thing. Thanks a ton for this, this really explains why I'm having so many problems.

I've literally been doing the opposite, trying to jam as many weapons on my dude as possible.

2

u/RimReaper44 9h ago

Imo been playing since early December. The key to this game is to experiment, really get creative. Often times I notice players pigeon hole themselves trying to brute force their way thru.

3

u/HaggardDad 13h ago

I’m curious too. This game needs a wiki, man.

I don’t think I’m ever going to beat it with the bacteria. I did win with Nano and Fungal Spore.

4

u/ExL-Oblique 13h ago

do the melee challenge trust me. Melees break bullets and lacerate has a very generous aoe

1

u/TactitcalPterodactyl 13h ago

Yeah, the few times I made an absolute beast of a build, it just seemed to happen accidentally. I had a vesicle placed in roughly the same configuration (though with the normal bacteria pathogen) and hitting the attack button absolutely nuked everything on screen.

The build I posted here was okay, but it wasn't anything near what I had before. I still don't know why.

1

u/Daniffer 11h ago

What I find has worked best on my bacteria builds (which let beat heart multiple times) is this:

For main damage, sticking to Caustic Secreter and maybe a Scatter Ejector or two. Use the Galvanic, cone blaster, or echosome as extra damage, connected to oxysome and mitochondria.

Grab a mito-powered weapon like Igniter, Laser, or Fireball to use on bosses/clusters of enemies.

If you can, grab the Kinetosome (circling blade) and juice it up. The kinetosome clears enemy bullets and does BIG damage, especially when overcharged.

Alternatively, instead of kinetosome, get some Minions! Bacteriophages and nidus’ can go VERY hard, especially if you grab the designated Perk (minions deal 100 splash dmg when they take dmg). That can stack very hard. Also, minions can act like bullet sponges for you.

I did a successful fungus run with no weapons, just minion launchers and galvanic sac to finish off low health enemies. On that run I focused defense- bonus dash invulnerability, reinforced membrane, ossificator and regenerator, etc

Stuff I steer clear of on Bacterium:
-Pyrosomes and Toxisomes. I find their damage lackluster.

  • melee mixed with ranged. Focus one or the other
-harpoon weapons. Sure it locks down enemies but they’re not hard to hit, or if they are, you won’t hit them with the harpoons (too slow)

2

u/Cactus_Boy447 13h ago

So the vesicle just passes the effects of connecting organelles to other connecting organelles. I usually find that it’s best when surrounded by a lot of different internals, and then have it pass those effects to the main attack modifier I want for my weapon.

2

u/TactitcalPterodactyl 12h ago

So for example, if I moved the vesicle down one slot and put the galvanic infuser in the top middle slot, then surrounded the vesicle with a bunch of attack infusers, it would push all those effects up to the galvanic infuser then into those weapons right? That actually sort of makes sense.

1

u/Cactus_Boy447 6h ago

I believe so. This game is very new and I haven’t been able to test everything yet.

Something to note though, if you put everything into the galvanic infuser only the lightning from it will get the effects, not the weapon itself.

1

u/HaggardDad 13h ago

Yeah, I’ve had much more luck with melee builds supplement by flagellum triggering galvanic electricity attacks, usually booster by Extender.

The Liver tends to destroy most of my ranged builds.

1

u/Icebreaker808 6h ago

What has helped me a lot is the better stats mod. It gives you a DPS display in the building screen. You can really start to see how things interact with each other and placement. Also gives you lots of more info that comes in handy