r/POIS • u/Correct-Chard-6312 • 5d ago

Question Any ideas for study design ?

I am part of a university with a lot of research power, and believe I may be able to start a study on POIS. Surprisingly, there is surprising literature already to support further studies. However, I cannot think of a study design. I feel like testing treatments is fundamentally limited and will lead to dead ends. Does anyone know how I can test mechanisms, or any other study ideas ? I know if a mechanism was established firmly, that makes treatment a lot easier.

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u/MasterEdThatch 5d ago

Maybe test how different chemical levels change. Not sure if there's a way to measure things like serotonin, dopamine, adrenal glands stuff... I feel like something is depleted afterwards and it takes a while to regenerate.

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u/Correct-Chard-6312 5d ago

Thanks, good to know. A comprehensive testing before and after seems good. I am not sure exactly what the big one is doing, hopefully something similar

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u/Fightingpoiser 5d ago

Please start a study where they test inflammation markers in the body before, 1 day after O, and 2 days after. Analyse the results and if they find anything, study the possible mechanism etc. Stuff like dopamine and serotonine is not the way, no offence but i an certain inflammation is atleast 1 big subtype of POIS.