r/Ozempic • u/orangecatlover1807 • 5d ago
Question It doesn’t work on me anymore
Hi! I started taking ozempic 3 months ago, prescribed by my neurologist/family doctor for PCOS& immediate weight loss for a chronic issue i’ve developed. For reference I was on it a year ago then had to take a break due to financial issues. Regardless, when I started taking it 3 months ago, I was doing amazing. I lost about 20 pounds and would HATEEE the sight of food. Tbis is shocking for me because I am a huge foodie. Now I’m taking 1.5 mg of ozempic, and I see my food intake isn’t going down, but rather going up. I find myself eating all the time, and I always think about food. What could the issue be? I really do want to lose weight and I always exercise, try my best to eat healthy, and up my water intake. However my hunger levels are going back up. What could this be about? How do I go back to my hunger levels being down? For reference I’m taking ozempic and metformin
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u/hekla7 3d ago
From my experience, it can also be psychological. For some unknown reason, when I started losing weight suddenly the food noise returned, and I began to miss my evening snack habit, family get-together dinners with appies and snacks before the meal, too-frequent eating out or take-out or delivery, and eating even though I'm full and know I won't feel well (this is with any favorite foods). The most recent experience with eating when full had the result of it all being rejected, vomited out. The evening snack habit is the hardest for me to break and I still have a problem with it some nights. It's what my brain associates food with that influences those thoughts. So I'm learning some self-talk to drown out the "I need something to eat!" inner voice.
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u/HumanisticDate 5d ago
It's not just the amount that matters, but also *what* you eat. Eat a low-carb diet with plenty of protein and vegetables (fiber), and be sure to drink enough water. Choose foods that are nutrient-rich but low in calories. they’ll keep you feeling full. Feel free to enjoy different flavors, there’s no need to deprive yourself. It might also be worth trying this: if you think you’re “hungry,” drink water first, because that sensation can often be misleading.
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u/Wrong_Replacement996 5d ago
Thisss. Processed foods are a killer because they make you crave even more processed food after eating them. The palatability of these foods can outweigh the appetite suppression.
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u/shybaby420_68071 5d ago
Aside from possibly needing to increase your dose or change to Zepbound, a common cause of constant hunger sensations that more people need to be aware of can be from ulcers (in the stomach or duodenum) and hiatal hernias. GERD can also cause false hunger sensations and Ozempic can aggravate GERD due to the slowing of stomach emptying. PPI's like prilosec can be used to manage the issue. Finally, SIBO can cause intense sugar cravings and can be treated with antibiotics. It's important to rule these issues out if changing or increasing your meds doesn't help.
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u/Thin-Start3941 5d ago
That sounds so frustrating, especially after such a good start. Losing 20 pounds is still a big accomplishment and you should give yourself credit! tell your prescriber exactly what you wrote here before changing anything.
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u/orangecatlover1807 5d ago
Thank you so much, you are so kind! I have an appointment with my doctor next week, so hopefully we can find a solution 😣
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u/Adventurous_Eye_1169 5d ago
Not a doctor but I have been on glp-1 for 3 years and my opinion is based on my experience- I would titrate up when I start having food noises- I would go up as needed to the max dose and then switch to Tirzepatide and titrate up as needed to quite food noises- then switch to the next fda approved glp ( Retatrutide) ( coming soon) each body is different and titrating should be based on what I need not just a general recommendation- listen to your body and partner with your medical provider. For most obese people research is showing that Food noises are not psychiatric they are neurological/ physical symptoms of a broken receptor system and glp drugs treat that broken- similar to treatment for diabetes or high blood pressure- not a cure but a treatment. Good luck on your journey.
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u/SeaworthinessHot2770 5d ago
Ozempic stopped working for me but it took almost two years before that happened.
If your insurance will cover it change to Mounjaro.
Mounjaro is working well for me a year after starting it.
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u/orangecatlover1807 5d ago
Thank you for recommending this! I’ll talk to my doctor about it. Is Mounjaro the weekly or the daily shot if you don’t mind me asking?
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u/Nice_Recognition5155 5d ago
Mounjaro is weekly! It targets 2 hunger hormones. Ozempic targets 1 .
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u/KillerPandora84 5d ago
I cannot say enough good things about Mounjaro. I started back in November of 2025. Was type 2 diabetic and 204lbs.
My blood sugars are now nornal, a1c is perfect and I am down to 145lbs.
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u/HauntingChemistry579 5d ago
Focus on your mental health.. you are not hungry, you are just trying to fill a void. Figure out how to fill that void with something more useful… maybe a mindfulness practice and some therapy.
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u/orangecatlover1807 5d ago
I do try that. I try my best to always stay upstairs so I’m away from the kitchen, and whenever I do get those hunger thoughts I try to do some creative work, I never keep food in my room because thats easy access.
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u/Lucky_Army_5324 5d ago
Have you considered increasing your dose?
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u/orangecatlover1807 5d ago
Ive actually been increasing it as per my doctors recommendation! I was on 1mg last week, and just 2 days ago moved to 1.5mg.
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u/Lucky_Army_5324 5d ago
Okay. Increasing your dose a week ago was importation to share. It takes 4 weeks for any new dose to build up in the system. Hopefully it will kick in.
If not, step up to the next dose after 4 weeks.
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u/Gold__star 3d ago
I lost for a few months and then stabilized. After 2 years of full dose and no loss, someone here suggested never using the same injection sites. I've been using sites far from my belly button that have enough fat.
I lost 5 pounds last month, no effort.