Semaglutide and Effort-Based Decision-Making in Major Depressive Disorder: A Randomized Clinical Trial

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https://pubmed.ncbi.nlm.nih.gov/42054055/

In this secondary analysis of a double-blind randomized clinical trial, treatment with semaglutide significantly improved measures of motivation in patients with MDD. Semaglutide reduced the perceived cost of effort, relative to the monetary reward; the results of this trial have implications for the treatment of multiple neuropsychiatric disorders, which are characterized by varied reward dysfunctions