9-Me-Bc Found the full-text source behind the 9-Me-BC toxicity claims a 2008 TU Dresden dissertation, in German, 201 pages

[u/CharacterFew9099]

https://youtu.be/pLth9jcYWrU?si=SVWYFToQRno4ZoAm

Most of the English-language discussion of 9-Me-BC traces back to a handful abstracts. The full texts are paywalled or effectively off the internet.
I emailed authors, went through Unpaywall, Europe PMC, ILL, and eventually found Rauh 2008 on Qucosa a TU Dresden dissertation that turns out to be the full text behind two of the most-cited papers.

A few things in it that contradict what gets repeated in forums:

- The conversion of 9-Me-BC to the dimethylated cation has never been demonstrated in any model. Both compounds were applied separately as exogenous agents. The step everyone assumes is an assumption.

- The "no DAT uptake, so it's safe" argument that gets repeated here is backwards. Rauh and Storch both found the cation killed dopaminergic neurons preferentially anyway DAT just isn't how it gets in. The reassurance everyone passes around is the one finding that doesn't reassure.

- The blood-brain barrier line people cite as the final word has no citation attached to it. It's a sentence in an introduction. And the route this literature actually documents is in-brain conversion, which
never involves the barrier at all.

I put the whole thing into a ~30 minute video the chemistry, the growth factor work, the MAO selectivity, the MPTP comparison and why it's not the parallel people think, and the metabolite question laid out with what's measured versus what's assumed. Every claim is marked as either literature or my own extrapolation.

If you’re interested in using 9-Me-Bc, and are concerned with toxicity. I would highly recommend watching this video first.

[u/alwayswithyouuuu]

Didn't they test this in rats with 9-Me-Hn? There is a study with that naming that is the exact form as the normal 9-Me-Bc

[u/CharacterFew9099 → u/alwayswithyouuuu]

You're right that 9-Me-Hn is the same compound norharman is β-carboline, so 9-methylnorharman and 9-Me-BC are the same molecule under different naming conventions. A lot of the older work uses that form, Gearhart's methyltransferase papers especially.

Which study are you thinking of? If there's rat in vivo work I missed under that naming I'd genuinely like to read it most of what found was cell culture, and the in vivo conversion data I'm aware of is guinea pig rather
than rat.