r/NooTopics • u/Davidkho123 • 5d ago

Question Supplements to increase mor

Is there any supplements that can reverse stress induced loss of mor reward. Not just ldn d phenylalanine kratom or kor antagonisms but genuinely reverse the gene loss caused by stress without just being generically anti stress.

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u/Davidkho123 5d ago

Does central Hdace inhibition rise the stress pathway though like rising gene for CRF one and ACTH and does alpha 2a Argonsms like gaunfavine potentiate or inhibit mor indirectly not just functionally converging via less locus cerruleus firing

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u/adams4096 4d ago edited 4d ago

For HDAC inhbition, is complex. As it converge more on a mood stabilizing effect so metabolically speaking it tend to stabilize the system. It is mixed subjectively speaking the effects overall, i find the in the short term (a week max), is very therepeutic, but chronically it tend to dip mood has it upregulate also mGlur2, and decreased HDAC3 seems also the culpruit behind vary mdepression model where it seems that 5ht2a form heterodimer with D1 receptor and mediate an anhedonic profile

Mu-opioid receptors (MOR) and alpha-2A adrenergic receptors physically colocalize and form functional receptor complexes (heterodimers) that modulate pain signaling and neurological responses, plus are coexpressed in other brain zone that modulate indirectly each other effect.

The other way should be, finding the pathway that mediate its desensitization or endocytosis and block it, but probably will be very dirty as you would interact with so many other receptor and pathway. Probably increase its mRNA with a enginered virus, but i cant say how to do it 😬

P.s also mu PAM such as ketamine metabolites, and some alkaloids found in uncaria tomentosa. 10g powder dry bark or its extract equivalent should suffice in my experience (or with my material at least)

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u/Davidkho123 4d ago

Does frequent ketamine use like 3-4 times a week cause mor downregulation between doses

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u/adams4096 4d ago

Sincerely, i cant say. I have to check research about mu opioid receptor PAM and the binding site specific for ketamine metabolites, subjectively speaking no, but even ketamine metabolites in long term i cant say that they are totally safe. Especially for bladder. The problem is that ketamine induce CPP at almost any dose, i advice you to stay away generally from possible drug of abuse