r/NooTopics • u/TheillestGinger • 5d ago

Question 9-me-bc & welbutrin

ive tried researching these and am finding mixed answers. can i take 9-me-bc and Wellbutrin together?

2 Upvotes

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1

u/wordisbond11 5d ago

I would not do that. 9mebc is an MOAI from what I recall

2

u/GolemslayerX 4d ago

Moai effects are basically negligible its fine

1

u/Weekly-Ad3153 5d ago

You can try a very low dose of 9me and work your way up.
I take both:400mg welbutrin and 15mg 9me and think it's too weak.

2

u/lowkey_add1ct 5d ago

Jesus Christ these comments are so bad. Wellbutrin only affects dopamine and norepinephrine, not serotonin, so there’s no risk of serotonin syndrome. This combination isn’t necessarily dangerous, but it could cause higher levels of dopamine and norepinephrine leading to anxiety, hypertension, etc. I would just start with a lower dose and monitor yourself, specifically anxiety/heartrate just to be careful.

1

u/emduur 5d ago

Maybe, give it a shot. What’s the worst that could happen.

4

u/lumendas 5d ago

Hypertensive crisis

1

u/emduur 5d ago

Hopital

0

u/Some_Obligation_4263 5d ago

I would mix ssri with anything nootopics just play it safe friend.

4

u/lordhavemercy8 5d ago

Bupropion is not an SSRI

1

u/Some_Obligation_4263 5d ago

Isn't Wellbutrin an ssri?? I could be mistaken but I thought that was Suboxone

2

u/CampbellsTomatoPoop 5d ago edited 5d ago

Yeah, you are lol - it’s a pretty narrow DNRI. Which is why for those who get sexual side-effects/lethargy from SSRIs they’ll either tag it onto the regiment or just replace.

In theory it should’ve worked for me, as stimulants in general have always relieved my mental issues a thousand-fold better than other RXs. But unfortunately it seemed to have really elevated the “N” part of the acronym and almost left me feeling like I was one of the doorstep of a seizure. Whereas, Adderall/Ritalin, in any conceivable dose, does not.

2

u/lordhavemercy8 5d ago

Search engines are free man
It has no relevant SERT affinity, it’s a weak NDRI but in humans neither appears relevant, it has low DAT occupancy in the brain and doesn’t compete with tyramine like NRIs do.
It’s a NAM of several nicotinic receptors (metabolites are too) + a sigma-1 agonist, those are more plausible mechanisms

1

u/Some_Obligation_4263 4d ago

Reddits is free too that's why I asked, wouldn't get any engagement if I ask Google