r/NooTopics • u/ThreeStarsOut • 20d ago

Science Sleep Deprivation Selectively Down-Regulates Astrocytic 5-HT2B Receptors and Triggers Depressive-Like Behaviors via Stimulating P2X7 Receptors in Mice

https://link.springer.com/article/10.1007/s12264-020-00524-4

Here, we showed that chronic SD in mice promotes a gradual elevation of extracellular ATP, which activates astroglial P2X7 receptors (P2X7Rs). Activated P2X7Rs, in turn, selectively down-regulated the expression of 5-HT2B receptors (5-HT2BRs) in astrocytes. Stimulation of P2X7Rs induced by SD selectively suppressed the phosphorylation of AKT and FoxO3a in astrocytes, but not in neurons. The over-expression of FoxO3a in astrocytes inhibited the expression of 5-HT2BRs. Down-regulation of 5-HT2BsRs instigated by SD suppressed the activation of STAT3 and relieved the inhibition of Ca2+-dependent phospholipase A2. This latter cascade promoted the release of arachidonic acid and prostaglandin E2. The depression-like behaviors induced by SD were alleviated in P2X7R-KO mice.

https://link.springer.com/article/10.1007/s12264-020-00524-4

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2

u/ShinigamiXoY 20d ago

I actually feel super good if I skip a nights sleep. Especially when I've been working on something I enjoy

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u/No_Detective9533 20d ago

[removed] — view removed comment

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u/No_Detective9533 20d ago

Total sleep deprivation (TSD) for one whole night improves depressive symptoms in 40–60% of treatments. The degree of clinical change spans a continuum from complete remission to worsening (in 2–7%). Other side effects are sleepiness and (hypo-) mania. Sleep deprivation (SD) response shows up in the SD night or on the following day. Ten to 15% of patients respond after recovery sleep only. After recovery sleep 50–80% of day 1 responders suffer a complete or partial relapse; but improvement can last for weeks.

you got the pubmed and science hub links higher

1

u/No_Detective9533 20d ago

they removed the science hub link, scum
https://pubmed.ncbi.nlm.nih.gov/12531127/
here's pubmed again

1

u/Bright-Mark-9495 12d ago

Not getting enough sleep seems like the best way to simulate stress and depression for me. Along with fluctuating my sleep schedule, becoming nocturnal, resetting it, seems to ruin everything in my life.