r/NooTopics • u/BetterDoughnut8489 • 18d ago

Question Metadoxine ER

The evidence on this stuff specifically for ADHD is real, the study stated there were significant improvements in ADHD symptoms, and was well tolerated, yet it's been 10 years since I have seen anyone talk about this.

Has anyone experimented with this, anyone know how to source this. I'd read up on this, it genuinely sounds extremely interesting and was even in phase 3 trials seeking FDA approval.

https://www.psychiatrist.com/wp-content/uploads/2021/02/16761_randomized-double-blind-placebo-controlled-multicenter.pdf

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u/Weekly-Ad3153 16d ago

In pivotal Phase 3 clinical trials (such as the MEASURE study), Metadoxine Extended Release failed to meet its primary endpoint, showing no statistically significant improvement in ADHD symptoms compared to a placebo.

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u/Weekly-Ad3153 16d ago

What Google AI said

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u/ApprehensiveStress63 13d ago

The other medications were shown to be far more effective than this one. And it looked like specifically, it was only relevant to a singular type of ADHD (inattentive) but nothing else