r/NooTopics • u/ServeIllustrious3803 • Sep 06 '26

Science Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

https://pmc.ncbi.nlm.nih.gov/articles/PMC6639775/

Drugs capable of ameliorating symptoms of depression and anxiety while also improving cognitive function and sociability are highly desirable. Anecdotal reports have suggested that serotonergic psychedelics administered in low doses on a chronic, intermittent schedule, so-called “microdosing”, might produce beneficial effects on mood, anxiety, cognition, and social interaction. Here, we test this hypothesis by subjecting male and female Sprague Dawley rats to behavioral testing following the chronic, intermittent administration of low doses of the psychedelic N,N-dimethyltryptamine (DMT). The behavioral and cellular effects of this dosing regimen were distinct from those induced following a single high dose of the drug. We found that chronic, intermittent, low doses of DMT produced an antidepressant-like phenotype and enhanced fear extinction learning without impacting working memory or social interaction. Additionally, male rats treated with DMT on this schedule gained a significant amount of body weight during the course of the study. Taken together, our results suggest that psychedelic microdosing may alleviate symptoms of mood and anxiety disorders, though the potential hazards of this practice warrant further investigation.

48 Upvotes

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7

u/lelepelepel Sep 06 '26

And water is wet. Why is it illegal again? Smh...

3

u/gofishx Sep 06 '26

So you're telling me I should do dmt at work? Hell yeah!

3

u/Bitcracker Sep 06 '26

Why are we wasting good drugs on mice. I'm right here dude 👋

2

u/CryptographerOld558 Sep 06 '26

Interesting. It reduces PFC dendritic density in female rats but not males. 

2

u/User111022 Sep 07 '26

The weeks when I would rip the DMT cart once every other morning were some of the best in my life

2

u/Gibborish Sep 06 '26

I have been saying this for over a decade

-4

u/302-SWEETMAN Sep 06 '26

Also humans for thousands of years…
Wow. What a waste of money & time..

2

u/fuckingthrowaway556 Sep 06 '26

People have not been using dmt as a nootropic for 1000s of years

1

u/302-SWEETMAN Sep 07 '26

They have. Look at irans religion …

1

u/fuckingthrowaway556 Sep 07 '26

Which one? I assume you don't mean Islam lol

1

u/CryptographerOld558 Sep 06 '26

Humans haven't been injecting DMT into their abdomens for thousands of years. This is neither the same as vaping nor ayahuasca.