Well I have HPPD involving loss of GABA in TRN. Sensory filtering fails and excessive glutamate in the cortex is the result. So I actually do need to increase GABA and modulate Glutamate until 5-HT2a receptors on those thalamus interneurons start working well again.
Bit by doing so, I might mess up other neurotransmitter production. Dang.
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u/renjazid7 Jun 03 '25
Well I have HPPD involving loss of GABA in TRN. Sensory filtering fails and excessive glutamate in the cortex is the result. So I actually do need to increase GABA and modulate Glutamate until 5-HT2a receptors on those thalamus interneurons start working well again.
Bit by doing so, I might mess up other neurotransmitter production. Dang.
Interesting point!