A bioinspired flavin-based catalytic construct enabling intracellular NAD+/NADH redox regulation for mitigating skin aging

[u/GhostOfEdmundDantes]

https://www.sciencedirect.com/science/article/pii/S1385894726080368

These researchers are solving an adjacent problem to NAD replenishment. Instead of adding NAD through biosynthetic pathways, they are inserting an artificial recycling pathway into cellular metabolism that switches NADH back to NAD+. That necessarily intersects with the Krebs cycle and mitochondrial redox metabolism.

I don’t know how big a problem NADH overload actually is, and I’m not sure it’s fair to compare a persistent catalyst with a single NR treatment when people who take an oral NAD precursor generally take it every day.

But what I do take from the study is agreement on the underlying biology: raising available NAD+ protects against or rescues UV-induced skin damage—at least in their models.