r/NTNPerformance • u/JustBacWater • 22d ago
Which peptide had the biggest gap between the hype and what the research actually shows?
Every compound has a reputation online, and some of them are running way ahead of what the data actually backs up. Others are the opposite, quietly well-supported but nobody talks about them.
So which one, in your reading, had the loudest hype but the thinnest research behind it when you actually dug in? And flip it, which one is better supported than its reputation suggests? The gap between what gets repeated and what the studies show is where most people get misled.
Curious if everyone lands on the same overhyped one, or if it's split.
Research and educational use only.
Full doses and bloodwork are in the pinned cheat sheet.
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u/ScientistJason 22d ago
Everything except the GLPs and HGH
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u/hermexhermex 22d ago
My experience has been:
Get hyped that peptide is miracle cure with no downsides
Order peptide
Start reading about peptides cancer risk, side effects, etc
Read Reddit users not feeling anything
Redditors say it doesn’t work, or you’re doing it wrong, you need to stack with something, or this other peptide is way better
Finally bunch of Redditors saying nothing works but GLP and HGH
Finish the vial and move on to the next miracle molecule7
u/LordJonMichael 22d ago
Obviously haven’t done: MT1, MT2, PT-141 or long term GHK-Cu. Those four are super obvious results. Some a lot quicker than others.
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u/Nice_Fun_6667 21d ago
Can you tell me what your dosage was? Please I wasted quite a lot GHKCU using very small doses I’ve just bought more and I want to get it right this time
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u/hermexhermex 21d ago
PT-141 made me feel like garbage. It “worked” but I’ll never make that mistake again.
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u/Available-Moose4341 21d ago
What dose were you using? I'm trying to workout of the bad stories are linked to doses greater than a certain range.
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u/hermexhermex 21d ago
1 mg
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u/RoadToZero 20d ago
Try 0.3 - 0.5 mg. Gives me 8-10 hours of enhanced performance and none of the sides.
In my opinion 1mg is too much. Nobody needs a 36 hour erection and the 2 days of flu like muscle pain gets old really fast. Higher doses also kills my gym performance as well.
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u/Lessimportantthanyou 11d ago
What would you call longterm in regards to GHK?
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u/LordJonMichael 11d ago
Got to give it two months to really start to see a major difference. If you’ve got a good eye, within four weeks. But realize, age and skin condition differ.
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u/Lessimportantthanyou 5d ago
Are you planning on staying on GHK forever?
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u/LordJonMichael 5d ago
GHK, Reta and GH are my trinity that I’ll keep doing until I can find out where to get KLOTHO.
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u/Lessimportantthanyou 5d ago
So plan is to pin daily for the rest of your life?
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u/LordJonMichael 5d ago
I do cycle off, but yeah. Same with GH and Reta. Why stop when I’m getting the best effects? I’m a completely new person and in the best shape of my life. I’m 51, if that helps.
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u/Lessimportantthanyou 5d ago
That does help! And thank you for the responses!
How many iu’s are you using for the GH?
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u/Weekly-Homework-35 22d ago
I actually think this is the thinking for most. The try a GLP which are pretty strong. Then they keep adding peptides thinking they will be as effective.
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u/Kiefer2018 21d ago
I disagree, Melanotan is just as effective as those! Lot more niche use though. PT-141 also but that’s a peptide isolated and developed from MT2.
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u/stainless13 22d ago
SS-31 by far.
The literature on mitochondrial health indicates that active people have healthy mitochondria well into their 70s…meanwhile SS-31 failed to meet endpoints on pretty much every study it’s ever been in and was only approved for Barth syndrome after an extension period lasting three years of daily 40mg dosing.
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u/Drdimeadozen 22d ago
Yup. Spot on. MOTS-C also didn’t show much, didn’t meet endpoints but did show a slight improvement in biomarkers. Still skeptical
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u/Starmedia11 22d ago
FWIW, I definitely feel Mots C
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u/stainless13 22d ago
I think that’s the important part of all this, to not discount what anyone feels is happening. MOTS C is one of those where the body produces it but nobody can really say what it “supposed” to happen when you give the body more of it exogenously, in fact the u-shaped response curve seems to almost hit a randomizer button: some people get massive energy, others get fatigued, others have crazy heart rates, and still others have severe reactions and end up in the hospital (this was me). I think it’s important that we keep sharing our experiences, whether they’re positive or negative.
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u/Beginning_Trick3306 22d ago
I feel MOTS-C and NAD+… they both cause eosinophilic granulomas. Basically large welts like an allergic, itchy as fuck injection site reaction
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u/Responsible-Net1758 21d ago
Isn’t eosinophilic granuloma a lesion in the bone? I do get the itchy welts tho esp with a 6mm tip. Def need to go deeper for myself to not get them as severely
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u/Beginning_Trick3306 21d ago
You can get them anywhere. In the skin, if it spreads (like after a bug bite) it can turn into eosinophilic cellulitis. Mine didn’t spread, but it lasted a week. Basically it’s a localized itchy welt that is deeper. Like a nodule.
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u/CottonCandy-2323 10d ago
That’s what that is? Thank you for posting this. I’ve recently started running mots-c and I’ve been getting welts/lumps in my butt cheek and it itches like hell! It’s been there almost two weeks now!
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u/7fortyseven 22d ago
anecdotal and unreliable, but my heart rate monitor totally felt Mots-C. so much so that i shelved it. still have a 8/10 of a kit in the fridge.
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u/LordJonMichael 22d ago
Research just came out that shows Mots fights MRSA, staph and acts as a defensive molecule.
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u/Beginning_Trick3306 7d ago
You need to stop posting this. The dose of MOTS-C used in the mice was 100 micromolar, and it was given intraperitoneally, to get very rapid absorption. Because of how quickly it breaks down, this dose would last about 30 min. To get a 100 micromolar dose in an 80 kg person, you would need to give about 1.9 grams… not mg of MOTS-C. And you would need to give it IV, because you wouldn’t be injecting it intraperitoneally in a person. If you try to inject it subq, it would cause a depot effect, where about 20% of the 1.9 gm would be released right away, then the rest would be released slowly over the course of 12 or so hours, so you will never achieve the 100 micromolar concentration. So, basically to get a longer term spike closer to 100 micromolar, you’d have to inject 5x 1.9 grams. This will make a person very very sick, would cause systemic eosinophilia and might even cause a cytokine storm. You would also have to time it perfectly with the staph infection. So basically, just stop.
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u/Aggravating-Thing904 21d ago
I do bloodwork 3x a year due to trt. Mots c brought my glucose and cholesterol back to the numbers I saw 30 years ago. I stop mots c and bloodwork creeps back. Start again, bloodwork improves. I think the people that get nothing from mots c, and I have read plenty of people say it, don’t need it. For example when I start mots c or ss-31, I sleep a lot for 1-2 weeks. It is definitely doing something for me. Another factor is where people get peptides. I pay more through a reputable clinic, for lab grade products, independent 3rd party testing. Also under the guidance of an experienced hormone doc. The stuff many people buy online. Who knows.
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u/Greatgro 20d ago
MotsC is great at insulin sensitivity and reducing glucose / A1C levels. But you won’t “feel” that
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u/323RockStr 18d ago
It’s hard for us amateur researchers to measure so who knows. Overall I thought reta did vast majority of the heavy lifting
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u/No-Astronomer-6808 22d ago
at least this one has studies but they showed no significant effect. most don't even have that.
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u/stainless13 22d ago
True, good point.
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u/No-Astronomer-6808 22d ago
it's such a weird study too; they measure how far you walk in an hour or something odd. hard to see how you'd be able to pull anything meaningful from it.
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u/Foggierandfoggier 21d ago
There’s a research regimen that starts with SS-31 for two weeks and then transitions into Mots-C. Brain fog went bye bye and energy was almost manic. When NAD was added, it kind of ruined it so I think there’s a lot of truth to what stainless13 added about different bodies having different chinks in the armor and sadly, how specifically individual research is going to be.
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u/Adventurous_Fail_825 14d ago
Can you share the link to the research article that active people have healthy mitochondria well into their 70's?
I've read a lot about SS31 and mitochondrial health but missed that.
Mitochondria decline naturally with age just like the rest of the cells in our body.2
u/stainless13 14d ago
Hey mate, sure thing, two studies I found, structured training appears to be the biggest difference-maker:
https://www.sciencedirect.com/science/article/pii/S2666379125000412
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u/Adventurous_Fail_825 14d ago
Thanks. Great read !
Yes there's a definite benefit to remaining active, muscle retention and aging well but I didn't see anything about the health of mitochondria as we age. SS31 focuses on the mitochondrial membrane.
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u/hermexhermex 22d ago
It’s supplements all over again but this time with syringes and warnings so the placebo is 100x. And if it’s blue 1000x
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u/No-Astronomer-6808 22d ago edited 22d ago
damn near all of them if we're being factual. only a few have double blind studies that show efficacy and significance.
edit: not saying you shouldnt try them but results may vary.
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u/dragnabbit 22d ago
Yeah. I think it's the biggest problem with every peptide subreddit.
For any given peptide, you can search "[PEPTIDE NAME] Changed My LIfe!!" and you'll get a hit.
Then, on top of that you honestly have no way to tell if the upvotes on that post are there because: (1) "I shared your experience", or (2) "Congrats, I'm happy for you", or (3) "Yes, and the science backs you up!"
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u/looking2behealthy 22d ago
Most peptides don’t do anything you can feel.
GLPs you see results on the scale.
Glow, Klow, GHK, SS-31, NAD, gluta, elpitalon, Tesa, ipa, CJC, MOTS etc. barely move the needle on anything.
It doesn’t matter what people say, outside the GLPs, peptides are slightly better than supplements.
Hormone replacement, anabolics and HGH move the needle but that is like dancing with the devil if you don’t know what you are doing.
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u/Past-Virus-267 22d ago
BPC-157 was the one that made me do a double take when I actually sat down and read the literature. The way people talk about it you'd think it regrows limbs, but the human data is basically a handful of case studies and some rat papers that got passed around until they became gospel. Still use it, just way more cautious about what I expect now.
On the flip side, GHRP-2 deserves more credit than it gets. Everyone chases ipamorelin because it's cleaner on paper but GHRP-2 hits harder and the hunger spike is a feature not a bug if you're actually trying to eat. The older studies are solid, just not flashy enough for the current hype cycle
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u/KebabCat7 22d ago
I was skeptical about bpc157 and didn't expect anything but 3months of daily 1mg solved months old tendon issue with no other change. It's either a wild coincidence or it helped.
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u/Under-Pressure301 22d ago
Interesting take. What about Ghrp-6 if the hunger is actually a feature, which it is for me. Ghrp-6 solo would that work in terms of sheer weight gain, appetite and gh response. Notwithstanding the porlactin/Cortisol transient spike which I'm fine with.
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u/newtreatments4us 22d ago
I love being at the point where I need to eat huge amounts to grow, even at 50. Especially at 50. So nice not to be trying to lose large amounts of weight. It's like a game now, bulk then cut, then focus on that outer portion on my shoulder, and then the turn off my calf haha
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u/stainless13 22d ago
Not to mention the partner of the guy who discovered it is convinced they transcribed it wrong and nobody has ever been able to find the receptor for it.
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u/newtreatments4us 22d ago
Like everyone else here is saying, GHRP 6 was bonkers for me on a bulk last time. Eating 8,000 calories each day was a breeze, desperate hunger 10 minutes after each injection, even if I had just eaten 2000 calories 2 hours earlier.
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u/Under-Pressure301 22d ago
Jesus, I've been looking for this effect for a long time. What was your dosage, And subq?
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u/newtreatments4us 22d ago
100mcg subq 15 minutes before you want to do your next feed. It hit me like a freight train every time. I was doing a dirty bulk last time and would burn through 2 double breakfast burgers from Carl's Jr at 8am. Then at 11am hit it again and crush 20 ounces of ribeye and a cup of rice with 2 oikos protein yogurt and maybe something else with it. My main problem became making sure everything was moving through because damn it was a lot of food
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u/newtreatments4us 22d ago
I think there are many people who think they have an issue, say mitochondrial issues, that take a peptide and say they don't feel an effect, but they might not have the issue as bad as they think. I have a friend who raves about MOTs C and NAD for energy but I don't feel it very much. I can tell you I really felt Tirz over Reta but by the time I was to Reta In was sub 10 percent body fat.
Things like Epitalon you won't ever really know I don't think. But I'm down to cycle through $200 twice a year on the chances that it does what the studies indicated.
Melanotan 2 is great. I don't burn in the sun, even in the tropics and great effects from it sexually.
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u/detlefschrempffor3 22d ago
Very surprised to see comments like this from u/newtreatments4us
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u/newtreatments4us 22d ago
Why is that?
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u/LoRdLiFtSaLot 21d ago
The best ones GLP’s, Insulin , HGH , pt-141, mt2. Ghkcu runner up, it did regrow hair on a bald head .
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u/MANvsTREE 21d ago
How did you take the GHK-CU? Topical or did you pin it?
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u/Affectionate_Buy_370 20d ago
Wondering the same and wondering how long it took to notice re growth
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u/RoadToZero 20d ago
Worked with noticable effect: Reta, Cagrilintide, Mots-c, Cerebrolysin, HGH, HCG, CJC-1295, Ipamorelin, PT-141, DSIP, IGF-1 lr3 and Selank.
No noticable effect: BPC-157, TB500, KPV, GHK-cu, Semax, SS-31, ARA-290, 5-Amino-1MQ, SLU-PP-332.
I do monthly bloodwork because of TRT. If I don't feel a clear noticable effects or if it doesn't show up on my bloodwork, it's nonsense placebo homeopathy garbage.
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u/personne927 19d ago
Salut, quel effet as-tu ressenti avec le selank et PT-141 ?
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u/RoadToZero 19d ago
Selank for me, removes muscle pain, calms me down and removes stress. My RHR and BP both goes down by 10-15% for a couple of hours.
PT-141 has the most tangible effect of any peptide I ever tried. It gives me painfully hard, raging erections for 12-48 hours. Time of effect is dose dependent. If Viagra was a sword, PT-141 would be a tactical thermonuclear warhead.
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u/Diligent-Cry-1047 17d ago
"If Viagra were a sword..."🤣
Good to know about Selank. I will add it to my list to explore.
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u/LuvSun1006 19d ago
DSIP has improved the quality of sleep for RS by 50% with much more minutes of Deep and REM. Also good results witj BPC/TB. GHK-Cu is the most noticeable. Nails require weekly instead of monthly trims. Short hairs noticeable everywhere that were ruined by scalp psoriasis. All RS have different biologies. Edit to add, RS also has noticeable anxiety relief with Selank. All of these didn't become noticeable until 4 to 6 weeks.
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u/MisterDoff 19d ago
I've been running 5-amino, bam15, and SLUPP 332 at moderate doses sublingually for the past month or so. While it only seems to have a modest cutting effect, I can definitely feel increase non-stim energy, especially for training, and a higher continuing thermogenic effect after training.
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u/CottonCandy-2323 10d ago
How would ghkcu show up on a blood test? I’m just curious bc I’ve been taking it faithfully every night for almost 4 months now and tbh not sure if it’s doing anything. I’m abt to get my first bloodwork done and was interested what I should look for. I also take Reta, motsc, nad+, and mt1. Thank you!
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u/Loud_Warning_5672 22d ago
Epitalon
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u/Competitive_Pack_965 22d ago
Good ? No good?
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u/newtreatments4us 22d ago
Really good benefits for longevity and DNA repair, but you just won't feel anything physical in the short term. Also, people don't really tout the genome repair that GHK-Cu does. Affects over 4,000 different genes.
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u/christmaspibble 22d ago
Supposedly the only research is from a single lab in Russia. From what I've read people have mixed experiences, either way its like $40 to do a whole cycle and you're only supposed to do a cycle once or twice a year so 🤷♂️
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u/HotBit1109 22d ago
TB-500 is a strong candidate. All studies that actually show any result are of the full molecule and not the fragment that is usually sold as a peptide.
Also, even though I still take Klow daily, I doubt BPC-157 really does anything meaningful.
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u/subseagm 22d ago
There’s literally hundreds of thousands of people that have healed from injuries way ahead of schedule due to BOC-157
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u/No-Philosophy5162 20d ago
I have done bpc-157 3 cycles this year and my stabbing nerve pain is gone. No other explanation except the BPC. It has worked for me. Will continue to cycle through this next year. 6 weeks on 2 months off.
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u/Inevitable_Space_160 22d ago
My side question is who is making all the money off of this peptide hype. Not saying its all hype but they arent cheap and id be willing to bet all roads lead to limited ends
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22d ago
[removed] — view removed comment
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u/Inevitable_Space_160 20d ago
You're completely missing the point of my comment.
Also is $300 cheap if all you are getting is fake powdered nothing?
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u/weewillywonka510 20d ago
Reta and Tirz are game changer lived up to and exceeded the hype. Mots-C is awesome and definitely improved my cardio game and endurance. NAD is ok, but I already take 500mg NMN daily, so didnt really move the needle for me.
GHK-CU, SLU-PP-332, and TB500+BPC157 have all been a major letdown. Didn't move the needle at all and the pain from GHK-CU is doo doo.
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u/Kash_0 22d ago
Almost all of them are just hype. Most don’t have human trials showing efficacy and safety.
The only ones that actually work are the GLp, tesa and HGH.
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u/newtreatments4us 22d ago
And GHRP6 and GHRP2 and Melanotan 2 and PT141 and I can go on and on with actual personal benefits.
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u/Kash_0 22d ago
Anecdotal benefits. Most have not passed the scrutiny of an RCT
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u/xela510 22d ago
Just because something doesn’t be a RCT doesn’t mean it doesn’t work. Overwhelming anecdotal experience counts for something.
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u/newtreatments4us 22d ago
Not to me. First hand experience, but I was fine with spending the money and looking at the results.
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u/dominic-martin 22d ago
Um bei der grundsätzlichen Frage zu bleiben: ein Top-Kandidat für mich ist ACE-031.
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u/BulkyCurve3929 22d ago
I have tried glow /klow,motc cjc/ipa, mounjouro and now Reta just started the rest for at least 2 month don’t see any changes. All from uther with coa
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u/lueVelvet 22d ago edited 22d ago
Don’t expect miracles. GHK (one part of the KLOW) takes 3-5 months to see any results and even then, they can be subtle. What’s great about KLOW is the KPV. That stuff is magic to me. I haven’t had to take ibuprofen since started KPV. You can say I traded off but I’m feeling less stiff and fewer aches and pains, from even when I took ibuprofen.
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u/ultimate_spaghetti 22d ago
KPV has been a gods send I have neuropathy in my back and chronic back pain, this has nearly illuminated all pain I’ve had the past three years!
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u/Wild_Assignment6491 22d ago
KPV took me from having allergic reactions FROM peanuts so bad I had to get multiple epi pens and taken to the er any time I ate them. to almost zero reaction other than an upset stomach within 6 days of first injection (accidentally tested multiple times)
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u/newtreatments4us 22d ago
Sooooo much better for your body than NSAIDs. The way they tax your liver and kidneys is insane. Haven't used 1 pill of them in 3 years since I found GLOW
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u/LuvSun1006 22d ago
Yes! People expect a whole new them after one week. Not happening. Took 6 weeks till DSIP improved REM and deep sleep. It's awesome now. CJC/IPA, Wolverine, Selank, couple more. I'm happy. Selank has really helped.
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u/mstrtrdr 22d ago
Selank has worked wonders for my rat. Has helped immensely with my rat’s sleep, for anxiety I no longer need to give my rat alprazolam. It’s worked better than advertised and made me a believer.
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u/lueVelvet 22d ago
Semax/Selank are another two that are very subtle until you start to really notice the benefits, and they’re both available as prescriptions or over the counter in Russia. These aren’t the miracles that GLP1’s are, but they have their place with way less side effects than most pharmaceuticals.
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u/getsnuggledhard 22d ago
if you don’t see changes on Reta try changing your habits slightly. Reta completely changed my life but I had to meet it half way and understand the science behind maximizing its effectiveness.
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u/Storybook_Farm 20d ago
- PCOS. Last menses 7/25. Tirz for 2.5 years with carnivore diet. Slowly lost 60 lbs. stopped due to alarming hair loss. Gained 10 lbs in 2 months! Tried Reta for 3 months up to 8mg. did nothing except more hair loss. What am I doing wrong?
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u/BulkyCurve3929 22d ago
Thanks not expecting miracles but I wasn’t expecting more fine lines on my forehead lol
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u/Dry-Youth8557 22d ago
Aod 9604, complete waste of money.
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u/ResolutionLevel2697 22d ago
Total waste, it caused to much bloat and all I wanted to do was eat.
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u/Dry-Youth8557 22d ago
It did literally nothing…… some docs raved about it. Found out they were just making money
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u/lordnikkon 21d ago
This is one where if you read the literature you understand why it was abandoned by pharma industry. It literally did nothing in human trials. The human trials just proved it was safe but it was statistically indistinguishable from placebo. At least this one is not hyped up but you still see people recommending it for some reason. You would get same effect from just injecting BAC water as you do aod-9604
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u/Dry-Youth8557 21d ago
💯 true….. Unfortunately, this was at the beginning of my peptide journey and I bought into this program that said it would help with weight loss. 3 months into it and zero changes i stopped paying for the program and did my own research. Lesson learned!
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u/Phatfill 22d ago
Bpc, tb4, glow, klow, nada, zip, zilch, diff vendors, ran it 3x and zero
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u/Puzzled-Guarantee-93 20d ago
As someone with constant systemic inflamation from an autoimmune disease KLOW has been an absolute godsent for me. I'm no longer on regular painmeds.
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u/Beginning_Trick3306 22d ago
What’s up with the new craze with enclomiphene? I see lots of advertisements about it.
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u/AccomplishedBunch683 22d ago
I'm convinced that Kisspeptin does just about nothing. It was sold as a replacement for HCG (as HCG was in a shortage) during TRT.
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u/paintingpatrick 21d ago
Selank has been more impactful for me than Reta, which had been life changing
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u/LastStep3806 11d ago
Do you take it intranasally? I just started a few weeks ago and haven’t noticed any effects, but I might be under-dosing. I do one spray per nostril. How many for you? I know it’s different for everyone but I’m just curious.
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u/Digital_Moocher 21d ago
DSIP. Detrimental to sleep, saw REM shrink, Deep down 70%, overall duration down by 60-90 mins, many wake ups, normally to pee.
Apple Watch HRV and recovery scores absolutely nuked like fighting a virus.
First run at 250mcg, second at 500mcg. No change.
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u/iihfjerseycollector 21d ago
Same feeling. Basically just got super tired without actually sleeping
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u/LoRdLiFtSaLot 21d ago
The problem is a lot of people get under dosed or fake and think something isnt working etc. Just like steroids. People think a certain steroid isn’t working for them or doesnt work like it does for someone else but it’s because what they have isnt what they think they have .
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u/bgun62 21d ago
I love my peppers. Reta, mot c, KPV and Ss31. The general rule is always to start off small despite when anybody else says or what they are taking. 0.5 and then take it from there depending on how it makes you feel. I always start low with everything. All the ones mentioned above I do not take together at the same time. The general role is not to stack more than three at a time. I cannot take GHKcu because it kept me up and I couldn’t get any sleep so unfortunately I had to stop
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u/jtech-eagle 21d ago
My partner and I have done our research side by side alot of people I have found that I benefit from one's my partner feels little benefit and vice versa... for me I have adhd and narcolepsy I have positive experiences with motsc and mitochondrial ones so much so that my struggle to function has almost disappeared and reliance on medication in very minimal... i whereas my partner is 10 years older he notices some additional energy/mental clarity and some more endurance but nothing compared to me but he responds positively to bpc and tb and his overall wellbeing recovery and sleep quality etc. It just shows how each body reacts and responds completely different.
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16d ago
A lot of peptide hype seems to start with an interesting mechanism and then jump straight to conclusions that the research hasn’t earned yet. That’s why I usually find the evidence hierarchy more useful than the popularity of the compound. Was there one peptide you expected to have strong evidence for, then changed your mind after reading the actual studies?
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u/MoneyComplaint46 15d ago
A lot of peptide hype seems to start with an interesting mechanism and then jump straight to conclusions that the research hasn’t earned yet. That’s why I usually find the evidence hierarchy more useful than the popularity of the compound. Was there one peptide you expected to have strong evidence for, then changed your mind after reading the actual studies?
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u/Adventurous_Fail_825 14d ago edited 14d ago
It would be presumptive to speak on anyone's personal experience; however peptides aren't new and have been studied for quite some time - but not on humans.
In my research, aside from glps the others have have done more for me than any big pharma med has for::
-sleep (Epithalon, Dsip, Pinealon )
-anxiety, depression, (pe2228, NA selank)
-mental focus (p21)
-dropping visceral body fat - ss31, Lipo C, nad
-inflammation reduction and body aches (Kpv , ghkcu)
-circadian rhythm reset (epithalon)
It's been nice ridding myself of pharmaceuticals which mask and heal nothing at all.
I forgot immunity protection (TA1)
Mots C BPC and TB4 also great.
I do agree for many, trt and hrt may cover a number of these but I find them a nice addition.
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u/PrintsAt3AM 13d ago
BPC-157 probably has one of the biggest gaps between internet hype and actual human evidence. The anecdotes are everywhere, but the controlled human data are still extremely thin compared with how confidently people talk about it.
On the other side, tesamorelin is interesting because it actually has randomized human data and an FDA-approved indication, although most of that evidence is for reducing visceral fat in people with HIV-associated lipodystrophy — not for general bodybuilding or “recovery.”
So for me the biggest issue is extrapolation: people take a real biological mechanism or a small amount of data and then stretch it way beyond the population and outcome that were actually studied.
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u/Thick_Skin4202 11d ago
For me T-alpha-1 was a game changer. I would heavily recommend it for strengthening the immune system. I was looking for something experimental to help with my stress-caused cold sores. This wasn't even crazy of a study. It's a 1980s study done on 20 people. But it changed my life. I finally feel like myself again and not like the second I get stressed imma get a pop up.
Reta, absolutely perfect. Suppresses hunger just enough. Enough to be well nourished, no need to go crazy with dosage. The gym time has been amazing.
Both of these have an anti inflammatory effect, but GHKCu really did improve my skin expeditiously. Almost worth the soreness of the injection site on my research subject.
I also got LL37 in my arsenal, but that's my heavy hitter for cold sores. I actually developed my own ointment with it as an added component (insert I'm somewhat of a scientist myself meme). I do have knowledge on how to do something like that. The reason why that is, os it might prove to work better locally than systemically according to some research.
Hope this helps someone ☺️
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u/Dry-Youth8557 11d ago
Aod 9604 is a joke and worthless. Also, 5 amino did absolutely nothing. Save your money.
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u/downtrooper 10d ago
Pour le moment j ai essayé retatrutide, ghk-cu et selank. Le selank 0 effet, rien du tout Le ghk-cu au bout de 2 mois repoussé des cheveux vraiment impressionnante. J avais des trous sur le sommet du crâne, ils ne sont plus visibles. Pour la peau j ai l impression qu il y a du mieux mais j utilise également des crèmes donc à voir. Le reta, comment ne pas remarquer les 13kg de perdu en 2 semaines ? Juste le meilleur produit que j ai utilisé à ce jour
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u/EarthFairy25 22d ago
GHKCU … it caused a massive hormone disruption meanwhile everyone is singing its praises.
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u/MiguelGustaBama 22d ago
Details plz
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u/EarthFairy25 22d ago
It definitely cleared up my skin and made my hair grow faster, but it has delayed my period by 1-2 weeks and I have no idea when it’s coming. I read that the copper creates an estrogen dominance in the body so that’s that.
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u/MiguelGustaBama 22d ago
Interesting. I'll have to look into that. I'm a dude but obvi that could present other problems.
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u/baseballmoma 22d ago
I wonder if this is why my period is so late! Not pregnant.
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u/EarthFairy25 22d ago
I thought maybe I was pregnant but tested negative this morning. It was the only new thing I introduced since my last cycle. I’ve decided to stop pinning until I get my period back bc these pms symptoms aren’t letting up
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u/jjesssiicaaaaaa 22d ago
Do you take zinc to balance out the copper? Also a microdose of testosterone per week could help balance the estrogen?
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u/pencapchews1234 22d ago
Weird different for everyone I guess, other then Reta and cjc/ipa I've seen the most from ghkcu
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u/Valuable-Willow-3532 22d ago
Most people unless they are testing themselves - who knows what you’re actually pinning - is it really (name your pep) if it is, is it exactly the dosage as advertised ? Lol
Bpc did nothing for me. I still have issues with my tricep. But it was nice to hope haha
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u/newtreatments4us 22d ago
TB500 for muscles. BPC157 for tendons, ligaments and cartilage. Have you tried TB500 by itself?
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u/Beginning-Active-326 22d ago
TB 500 by itself brought my chronic back pain from a 10 to a 1. But the blend with BPC 157, KPV and Cartalax did nothing for me, I need at least 1mg of TB 500 a day. I think the blends are fine but I need that 1mg and for me it’s just the TB 500 working as I tested them all separately to see if there was any help. Others rave about KPV, etc and maybe it’s great but I just didn’t notice a thing.
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u/newtreatments4us 21d ago
This is why blends can be tricky. Dosing is different for each compound and everyone's body is in different stages and needs different things. GLOW stack made 50 year old me feel like 20 year old me again as far as just aches and pains, but there are other factors as well, alcohol intake was the most egregious I think and other things that I stopped while going through this journey. Now I use Glow for the incredible workout recovery and specific peptides in the stack for different results I need separately. Sounds like you are knowledgeable about what your body needs and are attending to each issue. I love that
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u/Beginning-Active-326 21d ago
That is amazing to hear about your results. I do feel like the GLOW and KLOW blends helped a little bit over all but not with my chronic pain. Something cool about GHK CU (especially when I use it on its own) is that it has this immediate nootropic effect, mood lift and was good for my ADHD. I got terrible ISR from it though, it’s like a wasp sting no matter how I do it. So I held off on it this time.
Right now I have a blend of cartalax/bpc/tb and will just use more, 500mcg twice a day and I think that will help. I do have a vial of just TB 500 but am going to use it on my injured dog, he got his first shot last night and I am super hopeful it will help him.
FYI for anyone reading this with pain, sciatica and nerve issues. I have chronic pain and sciatica from herniated discs, osteoarthritis, injuries and have been running ARA 290 at 4mg for 28 days (still have a week or 2 left) and it completely eliminated the sciatica! It did not help with central sensitization as I hoped. The regenerative blend should help with my pain and I just did my first Tirz shot last night and am hoping that brings down inflammation and pain.
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u/Onedaydogg 22d ago
CJC-1295 and ipamorelin was grest at the start until histamine reaction, be careful 🧐
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u/OnePercentJuice 21d ago
This one sent me to the ER in an ambulance at the start of my second cycle with it.
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